Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke

The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 7812 - 14
Main Authors:	Li, Wenlu, Mandeville, Emiri T., Durán-Laforet, Violeta, Fukuda, Norito, Yu, Zhanyang, Zheng, Yi, Held, Aaron, Park, Ji-Hyun, Nakano, Takafumi, Tanaka, Masayoshi, Shi, Jingfei, Esposito, Elga, Niu, Wanting, Xing, Changhong, Hayakawa, Kazuhide, Lizasoain, Ignacio, van Leyen, Klaus, Ji, Xunming, Wainger, Brian J., Moro, Maria A., Lo, Eng H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19.12.2022 Nature Publishing Group Nature Portfolio
Subjects:	14/28 631/378/2596/1308 631/378/2607 692/699/375/534 Animal models Animals ASCL1 protein Astrocytes Brain Brain damage Cell differentiation Cell signaling Cell Transdifferentiation Cells, Cultured Conversion Deprivation Endothelial Cells Endothelium Glucose Humanities and Social Sciences Ischemia Male Mice multidisciplinary Neural Stem Cells Neurogenesis Neuronal-glial interactions Neuroplasticity Oxygen Progenitor cells Science Science (multidisciplinary) Stroke
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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