Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Somatic cell nuclear transfer (SCNT) in mammals is an inefficient process that is frequently associated with abnormal phenotypes, especially in placentas. Recent studies demonstrated that mouse SCNT placentas completely lack histone methylation (H3K27me3)-dependent imprinting, but how it affects pla...

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Veröffentlicht in:	Nature communications Jg. 11; H. 1; S. 2150 - 12
Hauptverfasser:	Inoue, Kimiko, Ogonuki, Narumi, Kamimura, Satoshi, Inoue, Hiroki, Matoba, Shogo, Hirose, Michiko, Honda, Arata, Miura, Kento, Hada, Masashi, Hasegawa, Ayumi, Watanabe, Naomi, Dodo, Yukiko, Mochida, Keiji, Ogura, Atsuo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.05.2020 Nature Publishing Group Nature Portfolio
Schlagworte:	38/1 38/39 38/61 631/136/2435 631/337/176/1968 631/337/384 64/60 Animals Birth Birth rate Cellular Reprogramming - genetics Cellular Reprogramming - physiology Cloning Embryos Enlargement Epigenetics Expansion Female Gene expression Genes Genomic Imprinting Histology Histones Histones - metabolism Humanities and Social Sciences Imprinting Methylation Mice MicroRNAs - genetics miRNA multidisciplinary Multigene Family - genetics Nuclear transfer Phenotypes Placenta Placenta - metabolism Pregnancy Repressor Proteins - genetics RNA, Untranslated - genetics RNA, Untranslated - metabolism Science Science (multidisciplinary) Somatic cell nuclear transfer
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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