Attacking hepatitis B virus cccDNA – The holy grail to hepatitis B cure

HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune res...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 64; no. 1; pp. S41 - S48
Main Authors:	Lucifora, Julie, Protzer, Ulrike
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2016 Elsevier
Subjects:	Cancer cccDNA DNA, Circular - genetics DNA, Viral - genetics Gastroenterology and Hepatology Hepatitis B - virology Hepatitis B virus Hepatitis B virus - genetics Humans Life Sciences Liver Virus Replication - genetics IFNγ TDP cccDNA DSS TALENs Liver dHepaRG HuHEP LTβR TNF A3A IFN-α A3B PHH RCA rcDNA pf-rcDNA NTCP Hepatitis B virus HBV differentiated HepaRG Rolling circle amplification humanized liver-chimeric protein-free rcDNA interferon gamma tyrosyl-DNA-phosphodiesterase TAL effector nucleases interferon alfa lymphotoxin beta receptor tumor necrosis factor Na +-taurocholate cotransporting peptide primary human hepatocyte relaxed circular DNA disubstituted sulfonamides APOBEC3A APOBEC3B
ISSN:	0168-8278, 1600-0641, 1600-0641
Online Access:	Get full text
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