Attacking hepatitis B virus cccDNA – The holy grail to hepatitis B cure

HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune res...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 64; no. 1; pp. S41 - S48
Main Authors:	Lucifora, Julie, Protzer, Ulrike
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2016 Elsevier
Subjects:	Cancer cccDNA DNA, Circular - genetics DNA, Viral - genetics Gastroenterology and Hepatology Hepatitis B - virology Hepatitis B virus Hepatitis B virus - genetics Humans Life Sciences Liver Virus Replication - genetics IFNγ TDP cccDNA DSS TALENs Liver dHepaRG HuHEP LTβR TNF A3A IFN-α A3B PHH RCA rcDNA pf-rcDNA NTCP Hepatitis B virus HBV differentiated HepaRG Rolling circle amplification humanized liver-chimeric protein-free rcDNA interferon gamma tyrosyl-DNA-phosphodiesterase TAL effector nucleases interferon alfa lymphotoxin beta receptor tumor necrosis factor Na +-taurocholate cotransporting peptide primary human hepatocyte relaxed circular DNA disubstituted sulfonamides APOBEC3A APOBEC3B
ISSN:	0168-8278, 1600-0641, 1600-0641
Online Access:	Get full text
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Summary:	HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune response, and therefore it is responsible for chronicity of HBV infection. While little is known about the mechanisms involved in cccDNA formation, current research is accumulating data on the mechanisms regulating transcription from cccDNA, and the first potential targeting approaches have been reported. This review will summarize our knowledge about cccDNA biology and the latest advances in cccDNA targeting strategies in order to finally achieve an HBV cure.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0168-8278 1600-0641 1600-0641
DOI:	10.1016/j.jhep.2016.02.009