Attacking hepatitis B virus cccDNA – The holy grail to hepatitis B cure
HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune res...
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| Vydáno v: | Journal of hepatology Ročník 64; číslo 1; s. S41 - S48 |
|---|---|
| Hlavní autoři: | , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Netherlands
Elsevier B.V
01.04.2016
Elsevier |
| Témata: | |
| ISSN: | 0168-8278, 1600-0641, 1600-0641 |
| On-line přístup: | Získat plný text |
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| Abstract | HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune response, and therefore it is responsible for chronicity of HBV infection. While little is known about the mechanisms involved in cccDNA formation, current research is accumulating data on the mechanisms regulating transcription from cccDNA, and the first potential targeting approaches have been reported. This review will summarize our knowledge about cccDNA biology and the latest advances in cccDNA targeting strategies in order to finally achieve an HBV cure. |
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| AbstractList | HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune response, and therefore it is responsible for chronicity of HBV infection. While little is known about the mechanisms involved in cccDNA formation, current research is accumulating data on the mechanisms regulating transcription from cccDNA, and the first potential targeting approaches have been reported. This review will summarize our knowledge about cccDNA biology and the latest advances in cccDNA targeting strategies in order to finally achieve an HBV cure. Summary HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune response, and therefore it is responsible for chronicity of HBV infection. While little is known about the mechanisms involved in cccDNA formation, current research is accumulating data on the mechanisms regulating transcription from cccDNA, and the first potential targeting approaches have been reported. This review will summarize our knowledge about cccDNA biology and the latest advances in cccDNA targeting strategies in order to finally achieve an HBV cure. HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune response, and therefore it is responsible for chronicity of HBV infection. While little is known about the mechanisms involved in cccDNA formation, current research is accumulating data on the mechanisms regulating transcription from cccDNA, and the first potential targeting approaches have been reported. This review will summarize our knowledge about cccDNA biology and the latest advances in cccDNA targeting strategies in order to finally achieve an HBV cure.HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA minichromosome is a key intermediate in the HBV life cycle. Its location in the nucleus makes cccDNA a difficult target for antivirals and immune response, and therefore it is responsible for chronicity of HBV infection. While little is known about the mechanisms involved in cccDNA formation, current research is accumulating data on the mechanisms regulating transcription from cccDNA, and the first potential targeting approaches have been reported. This review will summarize our knowledge about cccDNA biology and the latest advances in cccDNA targeting strategies in order to finally achieve an HBV cure. |
| Author | Lucifora, Julie Protzer, Ulrike |
| Author_xml | – sequence: 1 givenname: Julie surname: Lucifora fullname: Lucifora, Julie organization: Cancer Research Center of Lyon (CRCL), Lyon 69008, France – sequence: 2 givenname: Ulrike surname: Protzer fullname: Protzer, Ulrike email: protzer@tum.de organization: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstrasse 30, 81675 Munich, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27084036$$D View this record in MEDLINE/PubMed https://hal.science/hal-01812699$$DView record in HAL |
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| Copyright | 2016 European Association for the Study of the Liver. European Association for the Study of the Liver. Copyright © 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. Distributed under a Creative Commons Attribution 4.0 International License |
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| Keywords | IFNγ TDP cccDNA DSS TALENs Liver dHepaRG HuHEP LTβR TNF A3A IFN-α A3B PHH RCA rcDNA pf-rcDNA NTCP Hepatitis B virus HBV differentiated HepaRG Rolling circle amplification humanized liver-chimeric protein-free rcDNA interferon gamma tyrosyl-DNA-phosphodiesterase TAL effector nucleases interferon alfa lymphotoxin beta receptor tumor necrosis factor Na +-taurocholate cotransporting peptide primary human hepatocyte relaxed circular DNA disubstituted sulfonamides APOBEC3A APOBEC3B |
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| Snippet | HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA... Summary HBV deposits a covalently closed circular DNA form, called cccDNA, in the nucleus of infected cells. As the central transcription template, the cccDNA... |
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| SubjectTerms | Cancer cccDNA DNA, Circular - genetics DNA, Viral - genetics Gastroenterology and Hepatology Hepatitis B - virology Hepatitis B virus Hepatitis B virus - genetics Humans Life Sciences Liver Virus Replication - genetics |
| Title | Attacking hepatitis B virus cccDNA – The holy grail to hepatitis B cure |
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