Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels. At the chromatin level, aging associates with progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1545 - 12
Main Authors:	Sarkar, Tapash Jay, Quarta, Marco, Mukherjee, Shravani, Colville, Alex, Paine, Patrick, Doan, Linda, Tran, Christopher M., Chu, Constance R., Horvath, Steve, Qi, Lei S., Bhutani, Nidhi, Rando, Thomas A., Sebastiano, Vittorio
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.03.2020 Nature Publishing Group Nature Portfolio
Subjects:	13 13/100 13/106 14 14/1 38 38/79 49 49/91 631/443/7 631/532/2435 631/61/2320 631/80 Adolescent Adult Age Aged Aged, 80 and over Aging Aging - physiology Animals Cell Nucleus - metabolism Cells, Cultured Cellular Reprogramming - physiology Cellular Senescence - physiology Chondrocytes Chromatin Deregulation DNA Methylation - physiology Embryos Endothelial Cells Epigenesis, Genetic - physiology Epigenetics Exhaustion Female Fibroblasts Gene expression Gene Expression Profiling Gene regulation Homeostasis Humanities and Social Sciences Humans Inflammation Intravital Microscopy Life span Male Mice Middle Aged multidisciplinary Muscle Cells Muscles Pluripotency Primary Cell Culture Rejuvenation - physiology Restoration RNA, Messenger - metabolism Science Science (multidisciplinary) Senescence Stem cell transplantation Stem Cells Young Adult
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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