Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety

Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric diseases including depression and anxiety disorders. Here we show that, in a rodent anxiety model induced by chronic restraint stress (CRS), the dysregulation occurs in basolateral amygdala projection neurons...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 2221 - 15
Main Authors:	Liu, Wei-Zhu, Zhang, Wen-Hua, Zheng, Zhi-Heng, Zou, Jia-Xin, Liu, Xiao-Xuan, Huang, Shou-He, You, Wen-Jie, He, Ye, Zhang, Jun-Yu, Wang, Xiao-Dong, Pan, Bing-Xing
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06.05.2020 Nature Publishing Group Nature Portfolio
Subjects:	13/51 14/19 14/34 631/378 631/443 64/60 9/74 Amygdala Amygdala - physiology Animals Anxiety Anxiety - metabolism Anxiety - physiopathology Anxiety disorders Basolateral Nuclear Complex - physiology Corticosterone - pharmacology Disorders Etiology Glutamic Acid - metabolism Humanities and Social Sciences Male Mental disorders Mice Mice, Inbred C57BL multidisciplinary Neural Pathways - physiology Neurons Neurons - metabolism Optogenetics Pathogenesis Prefrontal cortex Prefrontal Cortex - physiology Restraint, Physical Science Science (multidisciplinary) Stress Stress, Psychological
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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