Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade

Analyzing mouse tumor models in vivo, human T cells ex vivo, and human lung cancer samples, we provide direct evidence that NR2F6 acts as an immune checkpoint. Genetic ablation of Nr2f6 , particularly in combination with established cancer immune checkpoint blockade, efficiently delays tumor progres...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 1538 - 13
Main Authors:	Klepsch, Victoria, Hermann-Kleiter, Natascha, Do-Dinh, Patricia, Jakic, Bojana, Offermann, Anne, Efremova, Mirjana, Sopper, Sieghart, Rieder, Dietmar, Krogsdam, Anne, Gamerith, Gabriele, Perner, Sven, Tzankov, Alexandar, Trajanoski, Zlatko, Wolf, Dominik, Baier, Gottfried
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.04.2018 Nature Publishing Group Nature Portfolio
Subjects:	38 38/91 631/67/1059/2325 631/67/1612/1350 631/67/580 64 64/60 96 96/95 Ablation Animal models Animals B7-H1 Antigen - metabolism Biopsy Cancer COUP Transcription Factors - antagonists & inhibitors COUP Transcription Factors - metabolism CTLA-4 protein Deregulation Disease Progression Female Gene Silencing Heterozygote Humanities and Social Sciences Humans Immune checkpoint Immune response Immune System Lung cancer Lymphocytes Lymphocytes T Male Mice Mice, Inbred C57BL multidisciplinary Neoplasm Transplantation Neoplasms - immunology Neoplasms - pathology Non-small cell lung carcinoma PD-1 protein PD-L1 protein Programmed Cell Death 1 Receptor - metabolism Receptors, Steroid - antagonists & inhibitors Receptors, Steroid - metabolism Repressor Proteins RNA, Small Interfering - metabolism Science Science (multidisciplinary) Spleen - metabolism T-Lymphocytes - cytology Transcription Tumors Up-Regulation
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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