Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen

The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and mortality rates. However, high interindividual variability in response is observed, calling for a personalized approach to tamoxifen treatment. T...

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Bibliographic Details
Published in:	Clinical pharmacokinetics Vol. 54; no. 8; pp. 797 - 810
Main Authors:	de Vries Schultink, Aurelia H. M., Zwart, Wilbert, Linn, Sabine C., Beijnen, Jos H., Huitema, Alwin D. R.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.08.2015 Springer Nature B.V
Subjects:	Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Estrogen Antagonists - pharmacokinetics Estrogen Antagonists - pharmacology Female Humans Internal Medicine Medicine Medicine & Public Health Pharmacology/Toxicology Pharmacotherapy Precision Medicine - methods Review Review Article Tamoxifen - pharmacokinetics Tamoxifen - pharmacology Poor Metabolizer Tamoxifen Treatment Tamoxifen Therapeutic Drug Monitoring Overall Survival
ISSN:	0312-5963, 1179-1926, 1179-1926
Online Access:	Get full text
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