The famine exposure in early life and metabolic syndrome in adulthood

Epidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure to Chinese famine between 1959 and 1962 during fetal and childhood period was related with metabolic syndrome (MS) in adulthood. 6445 subjects from SPECT-Chin...

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Vydané v:Clinical nutrition (Edinburgh, Scotland) Ročník 36; číslo 1; s. 253 - 259
Hlavní autori: Wang, Ningjian, Wang, Xiaojin, Li, Qin, Han, Bing, Chen, Yi, Zhu, Chunfang, Chen, Yingchao, Lin, Dongping, Wang, Bingshun, Jensen, Michael D., Lu, Yingli
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.02.2017
Predmet:
adolescence
adulthood
adverse effects
Age Factors
Asian Continental Ancestry Group
Body Mass Index
Child
Child, Preschool
childhood
China - epidemiology
chronic diseases
Cross-Sectional Studies
diabetes
Early life
epidemiological studies
Famine
Female
Gastroenterology and Hepatology
Humans
Infant
Male
malnutrition
men
Metabolic syndrome
Metabolic Syndrome - epidemiology
Metabolic Syndrome - etiology
Pregnancy
Prenatal Exposure Delayed Effects - epidemiology
Prevalence
risk
Risk Factors
Rural Population
Sex Factors
Sex specific
Socioeconomic Factors
socioeconomic status
Starvation - complications
Starvation - epidemiology
women
Sex specific
MS
Early life
IDF
Metabolic syndrome
BP
HDL
HOMA-IR
GDP
Famine
TG
FPG
HbA1c
BMI
blood pressure
body mass index
homeostatic model assessment-insulin resistance
triglycerides
gross domestic product
glycated hemoglobin
high density lipoprotein
fasting plasma glucose
International Diabetes Federation
ISSN:0261-5614, 1532-1983, 1532-1983
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Shrnutí:Epidemiologic studies have revealed that early-life conditions influence later risk of chronic diseases. We aimed to explore whether exposure to Chinese famine between 1959 and 1962 during fetal and childhood period was related with metabolic syndrome (MS) in adulthood. 6445 subjects from SPECT-China study were divided into fetal-exposed (1959–1962), childhood-exposed (1949–1958), adolescence/young adult-exposed (1921–1948), non-exposed (1963–1974) and non-exposed (after 1975). MS was defined by the International Diabetes Federation criteria. The prevalences of MS in the non-exposed (1963–1974), fetal and childhood-exposed were 16.4%, 20.1% and 19.1% in men and 13.5%, 23.7% and 33.5% in women, respectively. After adjustment for age, compared with non-exposed (1963–1974), fetal and childhood-exposed women had significantly higher prevalences of MS (P < 0.05), but not in men. Famine exposure during the fetal period (OR 1.47, 95% CI 1.05, 2.07) and childhood (OR 1.80, 95% CI 1.22, 2.67) was associated with higher risk of MS in women after adjusting for age (both P < 0.05). Further adjustments for age, smoking, rural/urban residence and economic status did not significantly attenuate this association. Exposure to famine in early life had sex-specific association with MS. It also suggests the adverse effects of malnutrition might extend beyond the 'first 1000 days' and last 9 years. •Exposure to famine in early life had sex-specific association with metabolic syndrome.•Women were more prone to be associated with metabolic syndrome when exposed to famine during fetus and childhood period.•The adverse effects of undernutrition might extend beyond the ‘first 1000 days’.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0261-5614
1532-1983
1532-1983
DOI:10.1016/j.clnu.2015.11.010