Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo

Mycophenolic acid, a selective inhibitor of the de novo synthesis of guanosine nucleotides in T and B lymphocytes, has been proposed to inhibit human immunodeficiency virus (HIV) replication in vitro by depleting the substrate (guanosine nucleotides) for reverse transcriptase. Here we show that myco...

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Bibliographic Details
Published in:	Nature medicine Vol. 6; no. 7; pp. 762 - 768
Main Authors:	Chapuis, Aude G., Paolo Rizzardi, G., D'Agostino, Claudia, Attinger, Antoine, Knabenhans, Christian, Fleury, Sylvain, Acha-Orbea, Hans, Pantaleo, Giuseppe
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.07.2000 Nature Publishing Group
Subjects:	Anti-HIV Agents - therapeutic use Apoptosis Biomedical and Life Sciences Biomedicine Cancer Research CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD8 antigen CD8-Positive T-Lymphocytes - drug effects Dose-Response Relationship, Drug HIV Infections - drug therapy Human immunodeficiency virus 1 Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Infectious Diseases Lymphocyte Activation - drug effects Lymphocytes Metabolic Diseases Molecular Medicine mycophenolic acid Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - pharmacology Mycophenolic Acid - therapeutic use Neurosciences T-Lymphocytes - drug effects
ISSN:	1078-8956, 1546-170X
Online Access:	Get full text
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