Epidemiological Features of Clostridium difficile Colonizing the Intestine of Jordanian Infants

Clostridium difficile is commonly found in the intestine of infants without causing any disease. This study investigated the most important epidemiological features of C. difficile strains colonizing intestine of Jordanian infants. A total of 287 fecal samples were collected from infants admitted to...

Full description

Saved in:
Bibliographic Details
Published in:International journal of microbiology Vol. 2017; no. 2017; pp. 1 - 5
Main Authors: Abu-Khader, Eman N., Shehabi, Asem A., Badran, Eman F.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects:
Antibiotics
Antimicrobial agents
Breast feeding
Chemotherapy
Ciprofloxacin
Clostridium difficile
Colonization
Cross-resistance
Developing countries
Diarrhea
DNA topoisomerase
E coli
Epidemiology
Erythromycin
Escherichia coli
Feces
Genes
High resistance
Hospital patients
Hospitals
Infants
Infants (Newborn)
Intestine
LDCs
Medical colleges
Medical research
Medicine, Experimental
Metronidazole
Microbiological culture
Microbiology
Mortality
Moxifloxacin
Mutation
Neonates
Newborn babies
Nosocomial infections
Pediatrics
Toxins
Vancomycin
ISSN:1687-918X, 1687-9198
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Clostridium difficile is commonly found in the intestine of infants without causing any disease. This study investigated the most important epidemiological features of C. difficile strains colonizing intestine of Jordanian infants. A total of 287 fecal samples were collected from infants admitted to the Jordan University Hospital (JUH) over the period of 2015. Samples were cultured for C. difficile and their growth was identified using microbiological culture and PCR. The overall C. difficile colonization rate among hospitalized and nonhospitalized infants was 37/287 (12.9%). Neonates were less colonized than other infants (8.7% verses 19.5%). Colonization of the infants with C. difficile toxigenic strains (TcdA and TcdB) was observed in 54% of the isolates, whereas those colonized with nontoxigenic strains were 46% and only one isolate was positive for binary toxin. Breast feeding of infants is a significant factor associated with decreased colonization with C. difficile. All C. difficile strains were susceptible to vancomycin and metronidazole, while high resistance rate to ciprofloxacin (78.4%) and less resistance rate to erythromycin (29.7%) were detected among the isolates. The results showed that 40.5% of the isolates carried mutated gyrA and gyrB genes which have cross-resistance to ciprofloxacin and moxifloxacin. This study represents useful epidemiological features about C. difficile colonizing intestine of infants living in a developing country.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Academic Editor: Barbara H. Iglewski
ISSN:1687-918X
1687-9198
DOI:10.1155/2017/2692360