Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

Parkinson's disease (PD) is characterized by widespread alpha-synuclein pathology and neuronal loss, primarily of the nigrostriatal dopaminergic neurons. Inflammation has been implicated in PD, and alpha-synuclein can initiate microglial activation; however, the kinetics and distribution of inf...

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Bibliographic Details
Published in:	Experimental neurology Vol. 237; no. 2; pp. 318 - 334
Main Authors:	Watson, Melanie B., Richter, Franziska, Lee, Soo Kyung, Gabby, Lauryn, Wu, Jennifer, Masliah, Eliezer, Effros, Rita B., Chesselet, Marie-Françoise
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01.10.2012 Elsevier
Subjects:	Alpha-synuclein alpha-Synuclein - metabolism Animals Biological and medical sciences Brain - immunology Brain - metabolism Brain - pathology Cytokines Cytokines - biosynthesis Disease Models, Animal Enzyme-Linked Immunosorbent Assay Flow Cytometry Human viral diseases Humans Immunohistochemistry Indexing in process Infectious diseases Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Medical sciences Mice Microglia Microglia - metabolism Neurodegeneration Neurology Overexpression Parkinson Disease - immunology Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Real-Time Polymerase Chain Reaction T-Lymphocytes - immunology Toll-Like Receptors - metabolism Transgenic Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Parkinson's disease CTX Transgenic PFA SPECT IBA-1 STR TGF‐β Neurodegeneration SN TLR Alpha-synuclein PBS TBS Cytokines IP Inflammation IL-1β Thy1-aSyn Microglia CRB Overexpression PD TH TNF-α ND DA Human Nervous system diseases Neuroglia Rodentia Cytokine Parkinson disease Cerebral disorder Vertebrata Mammalia Mouse Animal Central nervous system disease Degenerative disease Extrapyramidal syndrome
ISSN:	0014-4886, 1090-2430, 1090-2430
Online Access:	Get full text
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