Exosomes and Exosomal miRNA in Respiratory Diseases

Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their conten...

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Vydáno v:Mediators of inflammation Ročník 2016; číslo 2016; s. 1 - 11
Hlavní autoři: Mirsaeidi, Mehdi, Movassaghi, Masoud, Garssen, Johan, Mortaz, Esmaeil, Alipoor, Shamila D., Adcock, Ian M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016
John Wiley & Sons, Inc
Wiley
Témata:
Animals
Biomarkers
Body fluids
Breastfeeding & lactation
Clinical trials
Colleges & universities
Communication
Development and progression
Exosomes - genetics
Fluids
Health aspects
Hostages
Humans
Lipids
Lung diseases
Medicine
MicroRNA
MicroRNAs - genetics
Physiology
Proteins
Respiratory Tract Diseases - genetics
Respiratory Tract Diseases - metabolism
Review
RNA, Messenger - genetics
RNA, Untranslated - genetics
Signal transduction
Tuberculosis
Los Angeles California
ISSN:0962-9351, 1466-1861, 1466-1861
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Popis
Shrnutí:Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly miRNAs, to both neighboring and distal cells, they are considered important in cell-cell communication. Recent evidence has shown their possible importance in the pathogenesis of several pulmonary diseases. The differential expression of exosomes and of exosomal miRNAs in disease has driven their promise as biomarkers of disease enabling noninvasive clinical diagnosis in addition to their use as therapeutic tools. In this review, we summarize recent advances in this area as applicable to pulmonary diseases.
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Academic Editor: Yaozu Xiang
ISSN:0962-9351
1466-1861
1466-1861
DOI:10.1155/2016/5628404