Retinal Vascular Caliber as a Biomarker for Diabetes Microvascular Complications

[...]investigators have attempted over the decades to identify early changes in the retinal vessels in diabetes and determine whether they could inform about the development of retinopathy and other complications. [...]the incremental value of a novel biomarker over standard available biomarkers sho...

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Vydáno v:	Diabetes care Ročník 36; číslo 3; s. 750 - 759
Hlavní autoři:	Ikram, M. Kamran, Cheung, Carol Y., Lorenzi, Mara, Klein, Ronald, Jones, Teresa L.Z., Wong, Tien Yin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Alexandria, VA American Diabetes Association 01.03.2013
Témata:	Animals Biological and medical sciences Biological markers Biomarkers Biomarkers - metabolism Blood circulation disorders Cardiovascular disease Complications and side effects Demographic aspects Diabetes Diabetes Complications - metabolism Diabetes. Impaired glucose tolerance Diabetic Nephropathies - metabolism Diabetic Neuropathies - metabolism Diabetic retinopathy Diabetic Retinopathy - metabolism Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Health aspects Humans Medical sciences Metabolic diseases Miscellaneous Mortality Patients Public health. Hygiene Public health. Hygiene-occupational medicine Review Risk factors Stroke - metabolism Australia Endocrinopathy Human Nutrition Diabetes mellitus Biological marker Metabolic diseases Cardiovascular disease Retina Eye Vascular disease Visual system Microangiopathy Blood vessel Circulatory system Endocrinology
ISSN:	0149-5992, 1935-5548, 1935-5548
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Popis
Shrnutí:	[...]investigators have attempted over the decades to identify early changes in the retinal vessels in diabetes and determine whether they could inform about the development of retinopathy and other complications. [...]the incremental value of a novel biomarker over standard available biomarkers should be assessed not only with standard statistical measures such as the area under the curve (AUC) of the receiver operating characteristic curve or C-statistic, but also with more recently developed measures such as weighted net reclassification index (wNRl) and net benefit (NB) (5).
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0149-5992 1935-5548 1935-5548
DOI:	10.2337/dc12-1554