Retinal Vascular Caliber as a Biomarker for Diabetes Microvascular Complications

[...]investigators have attempted over the decades to identify early changes in the retinal vessels in diabetes and determine whether they could inform about the development of retinopathy and other complications. [...]the incremental value of a novel biomarker over standard available biomarkers sho...

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Bibliographic Details
Published in:Diabetes care Vol. 36; no. 3; pp. 750 - 759
Main Authors: Ikram, M. Kamran, Cheung, Carol Y., Lorenzi, Mara, Klein, Ronald, Jones, Teresa L.Z., Wong, Tien Yin
Format: Journal Article
Language:English
Published: Alexandria, VA American Diabetes Association 01.03.2013
Subjects:
Animals
Biological and medical sciences
Biological markers
Biomarkers
Biomarkers - metabolism
Blood circulation disorders
Cardiovascular disease
Complications and side effects
Demographic aspects
Diabetes
Diabetes Complications - metabolism
Diabetes. Impaired glucose tolerance
Diabetic Nephropathies - metabolism
Diabetic Neuropathies - metabolism
Diabetic retinopathy
Diabetic Retinopathy - metabolism
Diagnosis
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Health aspects
Humans
Medical sciences
Metabolic diseases
Miscellaneous
Mortality
Patients
Public health. Hygiene
Public health. Hygiene-occupational medicine
Review
Risk factors
Stroke - metabolism
Australia
Endocrinopathy
Human
Nutrition
Diabetes mellitus
Biological marker
Metabolic diseases
Cardiovascular disease
Retina
Eye
Vascular disease
Visual system
Microangiopathy
Blood vessel
Circulatory system
Endocrinology
ISSN:0149-5992, 1935-5548, 1935-5548
Online Access:Get full text
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Description
Summary:[...]investigators have attempted over the decades to identify early changes in the retinal vessels in diabetes and determine whether they could inform about the development of retinopathy and other complications. [...]the incremental value of a novel biomarker over standard available biomarkers should be assessed not only with standard statistical measures such as the area under the curve (AUC) of the receiver operating characteristic curve or C-statistic, but also with more recently developed measures such as weighted net reclassification index (wNRl) and net benefit (NB) (5).
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ISSN:0149-5992
1935-5548
1935-5548
DOI:10.2337/dc12-1554