Retinal Vascular Caliber as a Biomarker for Diabetes Microvascular Complications
[...]investigators have attempted over the decades to identify early changes in the retinal vessels in diabetes and determine whether they could inform about the development of retinopathy and other complications. [...]the incremental value of a novel biomarker over standard available biomarkers sho...
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| Published in: | Diabetes care Vol. 36; no. 3; pp. 750 - 759 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Alexandria, VA
American Diabetes Association
01.03.2013
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| Subjects: | |
| ISSN: | 0149-5992, 1935-5548, 1935-5548 |
| Online Access: | Get full text |
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| Abstract | [...]investigators have attempted over the decades to identify early changes in the retinal vessels in diabetes and determine whether they could inform about the development of retinopathy and other complications. [...]the incremental value of a novel biomarker over standard available biomarkers should be assessed not only with standard statistical measures such as the area under the curve (AUC) of the receiver operating characteristic curve or C-statistic, but also with more recently developed measures such as weighted net reclassification index (wNRl) and net benefit (NB) (5). |
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| AbstractList | [...]investigators have attempted over the decades to identify early changes in the retinal vessels in diabetes and determine whether they could inform about the development of retinopathy and other complications. [...]the incremental value of a novel biomarker over standard available biomarkers should be assessed not only with standard statistical measures such as the area under the curve (AUC) of the receiver operating characteristic curve or C-statistic, but also with more recently developed measures such as weighted net reclassification index (wNRl) and net benefit (NB) (5). |
| Audience | Professional |
| Author | Jones, Teresa L.Z. Ikram, M. Kamran Lorenzi, Mara Klein, Ronald Cheung, Carol Y. Wong, Tien Yin |
| Author_xml | – sequence: 1 givenname: M. Kamran surname: Ikram fullname: Ikram, M. Kamran organization: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Departments of Epidemiology and Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands, Department of Ophthalmology, National University of Singapore, Singapore – sequence: 2 givenname: Carol Y. surname: Cheung fullname: Cheung, Carol Y. organization: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore – sequence: 3 givenname: Mara surname: Lorenzi fullname: Lorenzi, Mara organization: Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts – sequence: 4 givenname: Ronald surname: Klein fullname: Klein, Ronald organization: Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin – sequence: 5 givenname: Teresa L.Z. surname: Jones fullname: Jones, Teresa L.Z. organization: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland – sequence: 6 givenname: Tien Yin surname: Wong fullname: Wong, Tien Yin organization: Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Department of Ophthalmology, National University of Singapore, Singapore, Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia |
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| Copyright | 2014 INIST-CNRS COPYRIGHT 2013 American Diabetes Association Copyright American Diabetes Association Mar 2013 2013 by the American Diabetes Association. 2013 |
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| Keywords | Endocrinopathy Human Nutrition Diabetes mellitus Biological marker Metabolic diseases Cardiovascular disease Retina Eye Vascular disease Visual system Microangiopathy Blood vessel Circulatory system Endocrinology |
| Language | English |
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| SubjectTerms | Animals Biological and medical sciences Biological markers Biomarkers Biomarkers - metabolism Blood circulation disorders Cardiovascular disease Complications and side effects Demographic aspects Diabetes Diabetes Complications - metabolism Diabetes. Impaired glucose tolerance Diabetic Nephropathies - metabolism Diabetic Neuropathies - metabolism Diabetic retinopathy Diabetic Retinopathy - metabolism Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Health aspects Humans Medical sciences Metabolic diseases Miscellaneous Mortality Patients Public health. Hygiene Public health. Hygiene-occupational medicine Review Risk factors Stroke - metabolism |
| Title | Retinal Vascular Caliber as a Biomarker for Diabetes Microvascular Complications |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23431093 https://www.proquest.com/docview/1318733684 https://www.proquest.com/docview/1312172897 https://pubmed.ncbi.nlm.nih.gov/PMC3579354 |
| Volume | 36 |
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