The ERK and JNK pathways in the regulation of metabolic reprogramming

Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved in cell growth. This metabolic reprogramming, known as aerobic glycolysis or the Warburg effect, allows tumor cells t...

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Bibliographic Details
Published in:	Oncogene Vol. 38; no. 13; pp. 2223 - 2240
Main Authors:	Papa, Salvatore, Choy, Pui Man, Bubici, Concetta
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.03.2019 Nature Publishing Group
Subjects:	631/67/2327 631/80/86 Animals Apoptosis Cancer Cancer cells Cancer research Cancer treatment Cell Biology Cell proliferation Cell Transformation, Neoplastic - metabolism Cellular Reprogramming - genetics Cellular Reprogramming - physiology Energy Metabolism - physiology Extracellular signal-regulated kinase Glucose Glucose metabolism Glutamine Glycolysis Glycolysis - physiology Human Genetics Humans Internal Medicine JNK Mitogen-Activated Protein Kinases - metabolism JNK Mitogen-Activated Protein Kinases - physiology MAP kinase MAP Kinase Signaling System - physiology Medicine Medicine & Public Health Metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Physiology Review Review Article Signal transduction Therapeutic applications Tumor cells Tumorigenesis Tumors United Kingdom
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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