The ERK and JNK pathways in the regulation of metabolic reprogramming

Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved in cell growth. This metabolic reprogramming, known as aerobic glycolysis or the Warburg effect, allows tumor cells t...

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Vydané v:	Oncogene Ročník 38; číslo 13; s. 2223 - 2240
Hlavní autori:	Papa, Salvatore, Choy, Pui Man, Bubici, Concetta
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.03.2019 Nature Publishing Group
Predmet:	631/67/2327 631/80/86 Animals Apoptosis Cancer Cancer cells Cancer research Cancer treatment Cell Biology Cell proliferation Cell Transformation, Neoplastic - metabolism Cellular Reprogramming - genetics Cellular Reprogramming - physiology Energy Metabolism - physiology Extracellular signal-regulated kinase Glucose Glucose metabolism Glutamine Glycolysis Glycolysis - physiology Human Genetics Humans Internal Medicine JNK Mitogen-Activated Protein Kinases - metabolism JNK Mitogen-Activated Protein Kinases - physiology MAP kinase MAP Kinase Signaling System - physiology Medicine Medicine & Public Health Metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Physiology Review Review Article Signal transduction Therapeutic applications Tumor cells Tumorigenesis Tumors United Kingdom
ISSN:	0950-9232, 1476-5594, 1476-5594
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Popis
Shrnutí:	Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved in cell growth. This metabolic reprogramming, known as aerobic glycolysis or the Warburg effect, allows tumor cells to sustain their fast proliferation and evade apoptosis. Interfering with oncogenic signaling pathways that regulate the Warburg effect in cancer cells has therefore become an attractive anticancer strategy. However, evidence for the occurrence of the Warburg effect in physiological processes has also been documented. As such, close consideration of which signaling pathways are beneficial targets and the effect of their inhibition on physiological processes are essential. The MAPK/ERK and MAPK/JNK pathways, crucial for normal cellular responses to extracellular stimuli, have recently emerged as key regulators of the Warburg effect during tumorigenesis and normal cellular functions. In this review, we summarize our current understanding of the roles of the ERK and JNK pathways in controlling the Warburg effect in cancer and discuss their implication in controlling this metabolic reprogramming in physiological processes and opportunities for targeting their downstream effectors for therapeutic purposes.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Literature Review-3 ObjectType-Review-3 content type line 23
ISSN:	0950-9232 1476-5594 1476-5594
DOI:	10.1038/s41388-018-0582-8