The ERK and JNK pathways in the regulation of metabolic reprogramming

Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved in cell growth. This metabolic reprogramming, known as aerobic glycolysis or the Warburg effect, allows tumor cells t...

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Vydáno v:	Oncogene Ročník 38; číslo 13; s. 2223 - 2240
Hlavní autoři:	Papa, Salvatore, Choy, Pui Man, Bubici, Concetta
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.03.2019 Nature Publishing Group
Témata:	631/67/2327 631/80/86 Animals Apoptosis Cancer Cancer cells Cancer research Cancer treatment Cell Biology Cell proliferation Cell Transformation, Neoplastic - metabolism Cellular Reprogramming - genetics Cellular Reprogramming - physiology Energy Metabolism - physiology Extracellular signal-regulated kinase Glucose Glucose metabolism Glutamine Glycolysis Glycolysis - physiology Human Genetics Humans Internal Medicine JNK Mitogen-Activated Protein Kinases - metabolism JNK Mitogen-Activated Protein Kinases - physiology MAP kinase MAP Kinase Signaling System - physiology Medicine Medicine & Public Health Metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Physiology Review Review Article Signal transduction Therapeutic applications Tumor cells Tumorigenesis Tumors United Kingdom
ISSN:	0950-9232, 1476-5594, 1476-5594
On-line přístup:	Získat plný text
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