Stopping syphilis transmission in Arctic communities through rapid diagnostic testing: The STAR study protocol

Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities and limited diagnostic infrastructure yield long delays ([greater than or equal to]14 days) between screening and treatment of cases. These ha...

Full description

Saved in:

Bibliographic Details
Published in:	PloS one Vol. 17; no. 9; p. e0273713
Main Authors:	Caya, Chelsea, Maheu-Giroux, Mathieu, Xia, Yiqing, Serhir, Bouchra, Morin, Veronique, Libman, Michael, Corsini, Rachel, Goldfarb, David M., Wong, Tom, Singh, Ameeta E., Yansouni, Cedric P.
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 12.09.2022
Subjects:	Accuracy Algorithms Arctic zone Biology and Life Sciences Blood Congenital diseases Control Decision making Diagnostic systems Diagnostic tests Disease control Disease transmission Epidemiology Ice environments Informed consent Laboratories Medical diagnosis Medical tests Medicine and Health Sciences Methods Outbreaks People and places Polar environments Prevention Public health Research and Analysis Methods Sexual health Sexually transmitted diseases STD Study Protocol Syphilis Arctic Nunavik Quebec Canada Canada Nunavut Territory Canada Arctic region Quebec Canada
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities and limited diagnostic infrastructure yield long delays ([greater than or equal to]14 days) between screening and treatment of cases. These hamper syphilis control efforts and may contribute to sustained transmission. Syphilis rapid diagnostic tests (RDTs) have been developed to make screening more accessible and to inform clinical decision-making within the same clinical encounter. These RDTs have been successfully deployed in several countries, but not yet in Canada. We describe the methodology of the "Stopping Syphilis Transmission in Arctic Communities Through Rapid Diagnostic Testing" (STAR) study, wherein the clinical and epidemiological impact of deploying a dual syphilis RDT in the context of ongoing transmission in Nunavut and Nunavik will be evaluated. In this prospective multisite field evaluation, sexually active individuals aged [greater than or equal to]14 years at risk for syphilis will be offered screening by an RDT at the point-of-care by non-laboratory trained registered nurses. Whole blood and serum specimens will be concurrently collected, when feasible, for rapid testing with an RDT containing both treponemal and non-treponemal components (Chembio DPP.sup.® Syphilis Screen & Confirm) and compared to laboratory-based reference testing according to a reverse sequence algorithm. The diagnostic accuracy of the RDT, using both whole blood and centrifuged serum specimens, will be validated under real-world conditions in remote Northern settings, outside of specialized laboratories. Additionally, screening-to-treatment time, case detection rates, and the number of infectious contacts averted by using the RDT relative to reference testing will be estimated. The impact of both diagnostic approaches on syphilis transmission dynamics will also be modeled. This study will provide much needed evidence for strengthening rapid responses to emerging syphilis outbreaks in remote Arctic regions, by supplementing traditional diagnostic strategies with an RDT to rapidly triage patients likely in need of treatment. These results will also inform the development and tailoring of future diagnostic strategies and public health responses to emerging outbreaks in the North.
AbstractList	Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities and limited diagnostic infrastructure yield long delays ([greater than or equal to]14 days) between screening and treatment of cases. These hamper syphilis control efforts and may contribute to sustained transmission. Syphilis rapid diagnostic tests (RDTs) have been developed to make screening more accessible and to inform clinical decision-making within the same clinical encounter. These RDTs have been successfully deployed in several countries, but not yet in Canada. We describe the methodology of the "Stopping Syphilis Transmission in Arctic Communities Through Rapid Diagnostic Testing" (STAR) study, wherein the clinical and epidemiological impact of deploying a dual syphilis RDT in the context of ongoing transmission in Nunavut and Nunavik will be evaluated. In this prospective multisite field evaluation, sexually active individuals aged [greater than or equal to]14 years at risk for syphilis will be offered screening by an RDT at the point-of-care by non-laboratory trained registered nurses. Whole blood and serum specimens will be concurrently collected, when feasible, for rapid testing with an RDT containing both treponemal and non-treponemal components (Chembio DPP.sup.® Syphilis Screen & Confirm) and compared to laboratory-based reference testing according to a reverse sequence algorithm. The diagnostic accuracy of the RDT, using both whole blood and centrifuged serum specimens, will be validated under real-world conditions in remote Northern settings, outside of specialized laboratories. Additionally, screening-to-treatment time, case detection rates, and the number of infectious contacts averted by using the RDT relative to reference testing will be estimated. The impact of both diagnostic approaches on syphilis transmission dynamics will also be modeled. This study will provide much needed evidence for strengthening rapid responses to emerging syphilis outbreaks in remote Arctic regions, by supplementing traditional diagnostic strategies with an RDT to rapidly triage patients likely in need of treatment. These results will also inform the development and tailoring of future diagnostic strategies and public health responses to emerging outbreaks in the North. Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities and limited diagnostic infrastructure yield long delays (≥14 days) between screening and treatment of cases. These hamper syphilis control efforts and may contribute to sustained transmission. Syphilis rapid diagnostic tests (RDTs) have been developed to make screening more accessible and to inform clinical decision-making within the same clinical encounter. These RDTs have been successfully deployed in several countries, but not yet in Canada.BACKGROUNDIntense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities and limited diagnostic infrastructure yield long delays (≥14 days) between screening and treatment of cases. These hamper syphilis control efforts and may contribute to sustained transmission. Syphilis rapid diagnostic tests (RDTs) have been developed to make screening more accessible and to inform clinical decision-making within the same clinical encounter. These RDTs have been successfully deployed in several countries, but not yet in Canada.We describe the methodology of the "Stopping Syphilis Transmission in Arctic Communities Through Rapid Diagnostic Testing" (STAR) study, wherein the clinical and epidemiological impact of deploying a dual syphilis RDT in the context of ongoing transmission in Nunavut and Nunavik will be evaluated. In this prospective multisite field evaluation, sexually active individuals aged ≥14 years at risk for syphilis will be offered screening by an RDT at the point-of-care by non-laboratory trained registered nurses. Whole blood and serum specimens will be concurrently collected, when feasible, for rapid testing with an RDT containing both treponemal and non-treponemal components (Chembio DPP® Syphilis Screen & Confirm) and compared to laboratory-based reference testing according to a reverse sequence algorithm. The diagnostic accuracy of the RDT, using both whole blood and centrifuged serum specimens, will be validated under real-world conditions in remote Northern settings, outside of specialized laboratories. Additionally, screening-to-treatment time, case detection rates, and the number of infectious contacts averted by using the RDT relative to reference testing will be estimated. The impact of both diagnostic approaches on syphilis transmission dynamics will also be modeled.METHODS AND DESIGNWe describe the methodology of the "Stopping Syphilis Transmission in Arctic Communities Through Rapid Diagnostic Testing" (STAR) study, wherein the clinical and epidemiological impact of deploying a dual syphilis RDT in the context of ongoing transmission in Nunavut and Nunavik will be evaluated. In this prospective multisite field evaluation, sexually active individuals aged ≥14 years at risk for syphilis will be offered screening by an RDT at the point-of-care by non-laboratory trained registered nurses. Whole blood and serum specimens will be concurrently collected, when feasible, for rapid testing with an RDT containing both treponemal and non-treponemal components (Chembio DPP® Syphilis Screen & Confirm) and compared to laboratory-based reference testing according to a reverse sequence algorithm. The diagnostic accuracy of the RDT, using both whole blood and centrifuged serum specimens, will be validated under real-world conditions in remote Northern settings, outside of specialized laboratories. Additionally, screening-to-treatment time, case detection rates, and the number of infectious contacts averted by using the RDT relative to reference testing will be estimated. The impact of both diagnostic approaches on syphilis transmission dynamics will also be modeled.This study will provide much needed evidence for strengthening rapid responses to emerging syphilis outbreaks in remote Arctic regions, by supplementing traditional diagnostic strategies with an RDT to rapidly triage patients likely in need of treatment. These results will also inform the development and tailoring of future diagnostic strategies and public health responses to emerging outbreaks in the North.DISCUSSIONThis study will provide much needed evidence for strengthening rapid responses to emerging syphilis outbreaks in remote Arctic regions, by supplementing traditional diagnostic strategies with an RDT to rapidly triage patients likely in need of treatment. These results will also inform the development and tailoring of future diagnostic strategies and public health responses to emerging outbreaks in the North. Background Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities and limited diagnostic infrastructure yield long delays (≥14 days) between screening and treatment of cases. These hamper syphilis control efforts and may contribute to sustained transmission. Syphilis rapid diagnostic tests (RDTs) have been developed to make screening more accessible and to inform clinical decision-making within the same clinical encounter. These RDTs have been successfully deployed in several countries, but not yet in Canada. Methods and design We describe the methodology of the “Stopping Syphilis Transmission in Arctic Communities Through Rapid Diagnostic Testing” (STAR) study, wherein the clinical and epidemiological impact of deploying a dual syphilis RDT in the context of ongoing transmission in Nunavut and Nunavik will be evaluated. In this prospective multisite field evaluation, sexually active individuals aged ≥14 years at risk for syphilis will be offered screening by an RDT at the point-of-care by non-laboratory trained registered nurses. Whole blood and serum specimens will be concurrently collected, when feasible, for rapid testing with an RDT containing both treponemal and non-treponemal components ( Chembio DPP ® Syphilis Screen & Confirm ) and compared to laboratory-based reference testing according to a reverse sequence algorithm. The diagnostic accuracy of the RDT, using both whole blood and centrifuged serum specimens, will be validated under real-world conditions in remote Northern settings, outside of specialized laboratories. Additionally, screening-to-treatment time, case detection rates, and the number of infectious contacts averted by using the RDT relative to reference testing will be estimated. The impact of both diagnostic approaches on syphilis transmission dynamics will also be modeled. Discussion This study will provide much needed evidence for strengthening rapid responses to emerging syphilis outbreaks in remote Arctic regions, by supplementing traditional diagnostic strategies with an RDT to rapidly triage patients likely in need of treatment. These results will also inform the development and tailoring of future diagnostic strategies and public health responses to emerging outbreaks in the North. Background Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities and limited diagnostic infrastructure yield long delays ([greater than or equal to]14 days) between screening and treatment of cases. These hamper syphilis control efforts and may contribute to sustained transmission. Syphilis rapid diagnostic tests (RDTs) have been developed to make screening more accessible and to inform clinical decision-making within the same clinical encounter. These RDTs have been successfully deployed in several countries, but not yet in Canada. Methods and design We describe the methodology of the "Stopping Syphilis Transmission in Arctic Communities Through Rapid Diagnostic Testing" (STAR) study, wherein the clinical and epidemiological impact of deploying a dual syphilis RDT in the context of ongoing transmission in Nunavut and Nunavik will be evaluated. In this prospective multisite field evaluation, sexually active individuals aged [greater than or equal to]14 years at risk for syphilis will be offered screening by an RDT at the point-of-care by non-laboratory trained registered nurses. Whole blood and serum specimens will be concurrently collected, when feasible, for rapid testing with an RDT containing both treponemal and non-treponemal components (Chembio DPP.sup.® Syphilis Screen & Confirm) and compared to laboratory-based reference testing according to a reverse sequence algorithm. The diagnostic accuracy of the RDT, using both whole blood and centrifuged serum specimens, will be validated under real-world conditions in remote Northern settings, outside of specialized laboratories. Additionally, screening-to-treatment time, case detection rates, and the number of infectious contacts averted by using the RDT relative to reference testing will be estimated. The impact of both diagnostic approaches on syphilis transmission dynamics will also be modeled. Discussion This study will provide much needed evidence for strengthening rapid responses to emerging syphilis outbreaks in remote Arctic regions, by supplementing traditional diagnostic strategies with an RDT to rapidly triage patients likely in need of treatment. These results will also inform the development and tailoring of future diagnostic strategies and public health responses to emerging outbreaks in the North. Background Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities and limited diagnostic infrastructure yield long delays (≥14 days) between screening and treatment of cases. These hamper syphilis control efforts and may contribute to sustained transmission. Syphilis rapid diagnostic tests (RDTs) have been developed to make screening more accessible and to inform clinical decision-making within the same clinical encounter. These RDTs have been successfully deployed in several countries, but not yet in Canada. Methods and design We describe the methodology of the “Stopping Syphilis Transmission in Arctic Communities Through Rapid Diagnostic Testing” (STAR) study, wherein the clinical and epidemiological impact of deploying a dual syphilis RDT in the context of ongoing transmission in Nunavut and Nunavik will be evaluated. In this prospective multisite field evaluation, sexually active individuals aged ≥14 years at risk for syphilis will be offered screening by an RDT at the point-of-care by non-laboratory trained registered nurses. Whole blood and serum specimens will be concurrently collected, when feasible, for rapid testing with an RDT containing both treponemal and non-treponemal components (Chembio DPP® Syphilis Screen & Confirm) and compared to laboratory-based reference testing according to a reverse sequence algorithm. The diagnostic accuracy of the RDT, using both whole blood and centrifuged serum specimens, will be validated under real-world conditions in remote Northern settings, outside of specialized laboratories. Additionally, screening-to-treatment time, case detection rates, and the number of infectious contacts averted by using the RDT relative to reference testing will be estimated. The impact of both diagnostic approaches on syphilis transmission dynamics will also be modeled. Discussion This study will provide much needed evidence for strengthening rapid responses to emerging syphilis outbreaks in remote Arctic regions, by supplementing traditional diagnostic strategies with an RDT to rapidly triage patients likely in need of treatment. These results will also inform the development and tailoring of future diagnostic strategies and public health responses to emerging outbreaks in the North.
Audience	Academic
Author	Serhir, Bouchra Caya, Chelsea Xia, Yiqing Maheu-Giroux, Mathieu Singh, Ameeta E. Libman, Michael Morin, Veronique Yansouni, Cedric P. Wong, Tom Corsini, Rachel Goldfarb, David M.
AuthorAffiliation	1 Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada 5 Nunavik Regional Board of Health and Social Services, Kuujjuaq, Quebec, Canada 9 Indigenous Services Canada, Government of Canada, Ottawa, Ontario, Canada 4 Laboratoire de Santé Publique du Québec /Institut National de Santé Publique du Québec, Sainte-Anne-de-Bellevue, Quebec, Canada 7 Divisions of Infectious Diseases and Medical Microbiology, McGill University Health Centre, Montreal, Quebec, Canada 10 Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada Federal University of Mato Grosso do Sul, BRAZIL 3 Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University, Montreal, Quebec, Canada 6 JD MacLean Centre for Tropical Diseases, McGill University Health Centre, Montreal, Quebec, Canada 11 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada 2 McGill Interdisciplinary Initiative in Infection a
AuthorAffiliation_xml	– name: 8 BC Children’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada – name: Federal University of Mato Grosso do Sul, BRAZIL – name: 9 Indigenous Services Canada, Government of Canada, Ottawa, Ontario, Canada – name: 4 Laboratoire de Santé Publique du Québec /Institut National de Santé Publique du Québec, Sainte-Anne-de-Bellevue, Quebec, Canada – name: 7 Divisions of Infectious Diseases and Medical Microbiology, McGill University Health Centre, Montreal, Quebec, Canada – name: 2 McGill Interdisciplinary Initiative in Infection and Immunity, Montreal, Quebec, Canada – name: 5 Nunavik Regional Board of Health and Social Services, Kuujjuaq, Quebec, Canada – name: 6 JD MacLean Centre for Tropical Diseases, McGill University Health Centre, Montreal, Quebec, Canada – name: 11 Department of Medicine, University of Alberta, Edmonton, Alberta, Canada – name: 10 Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada – name: 1 Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada – name: 3 Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University, Montreal, Quebec, Canada
Author_xml	– sequence: 1 givenname: Chelsea surname: Caya fullname: Caya, Chelsea – sequence: 2 givenname: Mathieu orcidid: 0000-0002-8363-4388 surname: Maheu-Giroux fullname: Maheu-Giroux, Mathieu – sequence: 3 givenname: Yiqing surname: Xia fullname: Xia, Yiqing – sequence: 4 givenname: Bouchra orcidid: 0000-0003-0735-0452 surname: Serhir fullname: Serhir, Bouchra – sequence: 5 givenname: Veronique surname: Morin fullname: Morin, Veronique – sequence: 6 givenname: Michael surname: Libman fullname: Libman, Michael – sequence: 7 givenname: Rachel surname: Corsini fullname: Corsini, Rachel – sequence: 8 givenname: David M. surname: Goldfarb fullname: Goldfarb, David M. – sequence: 9 givenname: Tom surname: Wong fullname: Wong, Tom – sequence: 10 givenname: Ameeta E. surname: Singh fullname: Singh, Ameeta E. – sequence: 11 givenname: Cedric P. orcidid: 0000-0002-4765-3469 surname: Yansouni fullname: Yansouni, Cedric P.
BookMark	eNqNkllr3DAUhU1JaZb2HxQqKJT0YaZavOahMIQugUAgM-2rkGXJVpAlV5JL5t9X7rglDqEUP8hcf-fI93BOkyNjjUiS1wiuESnQhzs7OsP0eojjNcRFnJFnyQmqCF7lGJKjB-_Hyan3dxBmpMzzF8kxyWGVVgifJGYb7DAo0wK_HzqllQfBMeN75b2yBigDNo4HxQG3fT8aFZSISOfs2HbAsUE1oFGsNdZPUBDxMO0F2HUCbHebW-DD2OzB4Gyw3OqXyXPJtBev5vMs-fb50-7y6-r65svV5eZ6xXNIwkqSjNQII4lJmuGilE0teVryFDJBclHWBKeSN7IQaUOgLKoqJYzUGcJNVtQ1JGfJm4PvoK2nc1Se4pgRJiUq80h8nImx7kXDhYl7azo41TO3p5YpuvxiVEdb-5NWaV6QrIoG57OBsz_GuDeNmXGhNTPCjoe7CCyLdELfPkKf_qOZapkWVBlp4718MqWbAhUog_A3tX6Cik8jesVjF6SK84Xg_UIQmSDuQ8tG7-nV9vb_2ZvvS_bdA7YTTIfOWz2GWBu_BNMDyJ313gn5N2QE6VTlP2nQqcp0rnKUXTyScRXY5B4XVvrf4l_eKfyX
CitedBy_id	crossref_primary_10_1016_j_cmi_2023_06_013 crossref_primary_10_1016_j_pathol_2024_09_011 crossref_primary_10_3389_fpubh_2024_1522698 crossref_primary_10_1136_bmjopen_2024_089021 crossref_primary_10_1016_j_eclinm_2025_103198
Cites_doi	10.1001/jamanetworkopen.2022.10559 10.1093/cid/cix326 10.14745/ccdr.v48i23a08 10.1136/sextrans-2016-053065 10.1016/j.jbi.2019.103208 10.1371/journal.pone.0091504 10.1371/journal.pone.0112190 10.1128/JCM.00624-10 10.1093/cid/cis928 10.14745/ccdr.v44i02a02 10.1371/journal.pmed.1001233 10.1016/j.jbi.2008.08.010 10.1128/spectrum.02642-21 10.1093/pch/pxx127 10.1038/nature03072
ContentType	Journal Article
Copyright	COPYRIGHT 2022 Public Library of Science 2022 Caya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2022 Caya et al 2022 Caya et al
Copyright_xml	– notice: COPYRIGHT 2022 Public Library of Science – notice: 2022 Caya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2022 Caya et al 2022 Caya et al
DBID	AAYXX CITATION IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM
DOI	10.1371/journal.pone.0273713
DatabaseName	CrossRef Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database Health & Medical Collection (Alumni) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Agricultural Science Database
Database_xml	– sequence: 1 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Public Health
DocumentTitleAlternate	Protocol for stopping syphilis transmission in Arctic communities through rapid diagnostic testing
EISSN	1932-6203
ExternalDocumentID	2713238186 PMC9467359 A717150086 10_1371_journal_pone_0273713
GeographicLocations	Arctic Nunavik Quebec Canada Canada Nunavut Territory Canada Arctic region Quebec Canada
GeographicLocations_xml	– name: Arctic – name: Nunavut Territory Canada – name: Quebec Canada – name: Canada – name: Arctic region – name: Nunavik Quebec Canada
GrantInformation_xml	– fundername: ; – fundername: ; grantid: PJT-162262
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI RC3 7X8 5PM AAPBV ABPTK BBAFP
ID	FETCH-LOGICAL-c603t-f353b121f2345278fdbfc48c40ae36e8b324fcdf7e4d30f79943a3b512d57bb03
IEDL.DBID	7RV
ISICitedReferencesCount	6
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000892376500023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Sun Oct 02 00:11:10 EDT 2022 Tue Nov 04 01:56:19 EST 2025 Sun Nov 09 14:32:32 EST 2025 Tue Oct 07 09:19:05 EDT 2025 Sat Nov 29 13:05:08 EST 2025 Sat Nov 29 10:12:12 EST 2025 Wed Nov 26 10:35:44 EST 2025 Wed Nov 26 09:23:08 EST 2025 Thu May 22 21:20:30 EDT 2025 Sat Nov 29 04:08:36 EST 2025 Tue Nov 18 22:23:00 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	9
Language	English
License	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c603t-f353b121f2345278fdbfc48c40ae36e8b324fcdf7e4d30f79943a3b512d57bb03
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: CPY reports being on an Independent Data Monitoring Committee (IDMC) for Medicago Inc. MM-G reports an investigator-sponsored research grant from Gilead Sciences Inc., and contractual arrangements from the Institut national de santé publique du Québec (INSPQ), the Institut d’excellence en santé et services sociaux (INESSS), the World Health Organization, and the Joint United Nations Programme on HIV/AIDS (UNAIDS), all outside of the submitted work. All other authors report no conflicts of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
ORCID	0000-0003-0735-0452 0000-0002-4765-3469 0000-0002-8363-4388
OpenAccessLink	https://www.proquest.com/docview/2713238186?pq-origsite=%requestingapplication%
PMID	36094912
PQID	2713238186
PQPubID	1436336
PageCount	e0273713
ParticipantIDs	plos_journals_2713238186 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9467359 proquest_miscellaneous_2713308749 proquest_journals_2713238186 gale_infotracmisc_A717150086 gale_infotracacademiconefile_A717150086 gale_incontextgauss_ISR_A717150086 gale_incontextgauss_IOV_A717150086 gale_healthsolutions_A717150086 crossref_primary_10_1371_journal_pone_0273713 crossref_citationtrail_10_1371_journal_pone_0273713
PublicationCentury	2000
PublicationDate	2022-09-12
PublicationDateYYYYMMDD	2022-09-12
PublicationDate_xml	– month: 09 year: 2022 text: 2022-09-12 day: 12
PublicationDecade	2020
PublicationPlace	San Francisco
PublicationPlace_xml	– name: San Francisco – name: San Francisco, CA USA
PublicationTitle	PloS one
PublicationYear	2022
Publisher	Public Library of Science
Publisher_xml	– name: Public Library of Science
References	J Papenburg (pone.0273713.ref012) 2022; 5 pone.0273713.ref027 AR Castro (pone.0273713.ref015) 2010; 48 A Zorzi (pone.0273713.ref019) 2017; 93 pone.0273713.ref022 pone.0273713.ref001 G Duhaime (pone.0273713.ref007) 2015 KL Hess (pone.0273713.ref020) 2014; 9 pone.0273713.ref024 pone.0273713.ref025 Y-P Yin (pone.0273713.ref014) 2013; 56 DC Mabey (pone.0273713.ref011) 2012; 9 Y Choudhri (pone.0273713.ref002) 2018; 44 NC Grassly (pone.0273713.ref028) 2005; 433 Statistics Canada (pone.0273713.ref006) AE Singh (pone.0273713.ref008) 2022; 48 (pone.0273713.ref003) 2016 EPF Chow (pone.0273713.ref021) 2017; 65 C Fortin (pone.0273713.ref026) 2015 pone.0273713.ref013 KW Coughlin (pone.0273713.ref023) 2018; 23 pone.0273713.ref010 RS Tsang (pone.0273713.ref017) 2022; 48 K Boulin (pone.0273713.ref005) 2019 PA Harris (pone.0273713.ref030) 2019; 95 Public Health Agency of Canada (pone.0273713.ref004) 2020 SK Vargas (pone.0273713.ref018) 2022; 10 LM Causer (pone.0273713.ref016) 2014; 9 Nunavik Regional Board of Health and Social Services (pone.0273713.ref009) 2019 PA Harris (pone.0273713.ref029) 2009; 42
References_xml	– ident: pone.0273713.ref010 – volume: 5 start-page: e2210559 issue: 5 year: 2022 ident: pone.0273713.ref012 article-title: Adequacy of serial self-performed SARS-CoV-2 rapid antigen-detection testing for longitudinal mass screening in the workplace publication-title: JAMA Netw Open doi: 10.1001/jamanetworkopen.2022.10559 – volume-title: Analyses de laboratoire recommandées pour le dépistage de la syphilis year: 2015 ident: pone.0273713.ref026 – volume: 48 start-page: 82 year: 2022 ident: pone.0273713.ref017 article-title: Laboratory evaluation of two point-of-care test kits for the identification of infectious syphilis publication-title: Can Commun Dis Rep – volume: 65 start-page: 389 year: 2017 ident: pone.0273713.ref021 article-title: Increased Syphilis Testing of Men Who Have Sex With Men: Greater Detection of Asymptomatic Early Syphilis and Relative Reduction in Secondary Syphilis publication-title: Clin Infect Dis doi: 10.1093/cid/cix326 – volume: 48 start-page: 102 year: 2022 ident: pone.0273713.ref008 article-title: Lessons from management of syphilis in Nunavut, Canada, 2012–2020 publication-title: Can Commun Dis Rep doi: 10.14745/ccdr.v48i23a08 – volume: 93 start-page: S51 year: 2017 ident: pone.0273713.ref019 article-title: Field evaluation of two point-of-care tests for syphilis among men who have sex with men, Verona, Italy publication-title: Sex Transm Infect doi: 10.1136/sextrans-2016-053065 – volume: 95 start-page: 103208 year: 2019 ident: pone.0273713.ref030 article-title: The REDCap consortium: Building an international community of software platform partners publication-title: J Biomed Inform doi: 10.1016/j.jbi.2019.103208 – ident: pone.0273713.ref022 – volume-title: Nunavik in Figures 2015—Full Version year: 2015 ident: pone.0273713.ref007 – ident: pone.0273713.ref024 – volume: 9 start-page: e91504 year: 2014 ident: pone.0273713.ref016 article-title: A Laboratory-Based Evaluation of Four Rapid Point-of-Care Tests for Syphilis publication-title: PLOS ONE doi: 10.1371/journal.pone.0091504 – volume: 9 start-page: e112190 year: 2014 ident: pone.0273713.ref020 article-title: Sensitivity and Specificity of Point-of-Care Rapid Combination Syphilis-HIV-HCV Tests publication-title: PLOS ONE doi: 10.1371/journal.pone.0112190 – volume-title: Annual Report 2018–2019 year: 2019 ident: pone.0273713.ref009 – ident: pone.0273713.ref013 – volume-title: Portrait des infections transmissibles sexuellement et par le sang (ITSS) au Québec: année 2018 et projections 2019 year: 2019 ident: pone.0273713.ref005 – volume: 48 start-page: 4615 year: 2010 ident: pone.0273713.ref015 article-title: Novel Point-of-Care Test for Simultaneous Detection of Nontreponemal and Treponemal Antibodies in Patients with Syphilis publication-title: J Clin Microbiol doi: 10.1128/JCM.00624-10 – volume: 56 start-page: 659 year: 2013 ident: pone.0273713.ref014 article-title: A Dual Point-of-Care Test Shows Good Performance in Simultaneously Detecting Nontreponemal and Treponemal Antibodies in Patients With Syphilis: A Multisite Evaluation Study in China publication-title: Clin Infect Dis doi: 10.1093/cid/cis928 – volume-title: Crude birth rate, age-specific fertility rates and total fertility rate (live births) ident: pone.0273713.ref006 – ident: pone.0273713.ref001 – volume: 44 start-page: 43 year: 2018 ident: pone.0273713.ref002 article-title: Infectious and congenital syphilis in Canada, 2010–2015 publication-title: Can Commun Dis Rep doi: 10.14745/ccdr.v44i02a02 – volume-title: Reportable communicable diseases in Nunavut, 2007–2014 year: 2016 ident: pone.0273713.ref003 – volume: 9 start-page: e1001233 year: 2012 ident: pone.0273713.ref011 article-title: Point-of-Care Tests to Strengthen Health Systems and Save Newborn Lives: The Case of Syphilis publication-title: PLOS Med doi: 10.1371/journal.pmed.1001233 – ident: pone.0273713.ref025 – volume: 42 start-page: 377 year: 2009 ident: pone.0273713.ref029 article-title: Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support publication-title: J Biomed Inform doi: 10.1016/j.jbi.2008.08.010 – ident: pone.0273713.ref027 – volume-title: Syphilis in Canada: Technical report on epidemiological trends, determinants and interventions year: 2020 ident: pone.0273713.ref004 – volume: 10 start-page: e0264221 year: 2022 ident: pone.0273713.ref018 article-title: Laboratory Evaluation of the DPP Syphilis Screen & Confirm Assay publication-title: Microbiol Spectr doi: 10.1128/spectrum.02642-21 – volume: 23 start-page: 138 year: 2018 ident: pone.0273713.ref023 article-title: Medical decision-making in paediatrics: Infancy to adolescence publication-title: Paediatr Child Health doi: 10.1093/pch/pxx127 – volume: 433 start-page: 417 year: 2005 ident: pone.0273713.ref028 article-title: Host immunity and synchronized epidemics of syphilis across the United States publication-title: Nature doi: 10.1038/nature03072
SSID	ssj0053866
Score	2.4489806
Snippet	Background Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most... Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most communities... Background Intense transmission of syphilis has emerged in some Canadian Arctic communities despite screening and prevention efforts. The remoteness of most...
SourceID	plos pubmedcentral proquest gale crossref
SourceType	Open Website Open Access Repository Aggregation Database Enrichment Source Index Database
StartPage	e0273713
SubjectTerms	Accuracy Algorithms Arctic zone Biology and Life Sciences Blood Congenital diseases Control Decision making Diagnostic systems Diagnostic tests Disease control Disease transmission Epidemiology Ice environments Informed consent Laboratories Medical diagnosis Medical tests Medicine and Health Sciences Methods Outbreaks People and places Polar environments Prevention Public health Research and Analysis Methods Sexual health Sexually transmitted diseases STD Study Protocol Syphilis
SummonAdditionalLinks	– databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3fb9MwELZQ4QEJMTZAK_uBQUjAQ7YkduyYtwpRgTSNaR3T3iLHjkulKYmaFIn_fneJWxbEBDz7c2Sf7-I72_cdIW_yxGohTBjEjOmAWxsFeQqGp5jWSqhEyo7A9PJEnp6mV1fq7Feg-NsNPpPRsZfpUV2VxRGyr0gsUns_ZkJgsDU9O1n_ecF2hfDpcXf1HGw__ic8qq-rZuBhDt9H3tpwplv_O9Qn5LF3Lemk14Vtcq8od8ij_lyO9ulGO2TbG3ND33nG6fdPSTlrK-RpmNPmZ40nLA1tcQ8DHcDDNLoo4auYTEVNn0-CLKzUl_ihS10vLLX9mz0EtcjcUc4_UNBBOruYnNOOxJYiJ0QFiveMfJt-uvj4OfCFGAIjQtYGjiUsj-LIxYwnsUydzZ3hqeGhLpgo0hy8MmeskwW3LHRSKc40y8GXsInM85A9J6MSZLJLKPiH3LoiyYWw3BqreVRAiGqUdUlorRoTtl6fzHiWciyWcZ11V28SopVemhkKOfNCHpNg06vuWTr-gn-JS5_1uaYbI88mENyChwxh3pi87hBIkVHiG5y5XjVN9uXr5T-AZucD0FsPchXMxGif9wDDQeqtAXJ_gIRFNoPmXVTU9YSaLIaZdB4X9lwr75-bX22a8aP4rq4sqlWPQU5IDoKXA6XfyBH5x4ct5eJ7x0OuYJNliXpx97j2yMMY00W6khv7ZNQuV8UBeWB-tItmedgZ7w0ma0df priority: 102 providerName: Public Library of Science
Title	Stopping syphilis transmission in Arctic communities through rapid diagnostic testing: The STAR study protocol
URI	https://www.proquest.com/docview/2713238186 https://www.proquest.com/docview/2713308749 https://pubmed.ncbi.nlm.nih.gov/PMC9467359 http://dx.doi.org/10.1371/journal.pone.0273713
Volume	17
WOSCitedRecordID	wos000892376500023&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Rb9MwELag4wEJDTZAK4xiEBLwkC6JkzjhBXXTKqZtJWpHVXiJEjsplaYka1Ik_j13jlOIhACJl3vxOYl9Z_vu4vuOkFeJK2PPE6ZhMxYbjpSWkfiw8AIWx4EXuJwrANP5BZ9M_MUiCHXArdLXKts9UW3UshAYIz-ywZtSx4v3vrwxsGoU_l3VJTRukx0LbWPQZz6dtzsxrGXP0-lyjFtHWjrDssjTIeK4cIt1jiO9KffK66LqWJzd-5K_HEDj-__76Q_IrjY96ajRlT1yK833yb0mbkebdKR9sqcXe0XfaETqtw9JPqsLxHFY0up7iRGYitZ4xoGOYLCNrnJ4KiZbUdHkmyBKK9UlgOg6LleSyuZOHzLViOyRL99R0FE6uxpNqQK5pYgZUYBiPiKfxqdXJx8MXajBEJ7JaiNjLkss28ps5rg29zOZZMLxhWPGKfNSPwGrLRMy46kjmZnxIHBYzBKwNaTLk8Rkj0kvB6EcEAr2oyOz1E08TzpSyNixUnBhRSAz15Qy6BPWyisSGsUci2lcR-rXHAdvppnNCKUcaSn3ibHtVTYoHn_hf46qEDW5qNtNIBqB8wsWNLiBffJScSCERo53dJbxpqqis4_zf2CaTTtMrzVTVsBIRKzzIuBzEJqrw3nY4QQhi07zASpuO6Aq-ql30LPVzN83v9g240Px3l2eFpuGBzEjHZh43lkE23lEfPJuS776qnDKAziEmRs8-fPLn5K7NqaUqLIch6RXrzfpM3JHfKtX1XqgFjTSBVfUB-qfWAOyc3w6CacDFUMBOg4vgJ4fD4FemudIeajoDGjofoEe4dll-PkHDGZlwg
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1fb5RAEN_U00QTo7ZqelrtajTWB1pgFxZMjLmoTS89z6Z3No0vCLtwXtIAHpymX8rP6Ay7nJIY9aUPPu-wwDB_l5nfEPIk8VTs-9K2XMZiiyvlWEkAiheyOA790BOiATA9GYnxODg9DY_WyPe2FwbLKlub2BhqVUg8I99zIZtq3Iv_qvxi4dQo_LvajtDQYnGYnn-DlK16OXwD3_ep6-6_nb4-sMxUAUv6NqutjHkscVwncxn3XBFkKskkDyS345T5aZBAiJFJlYmUK2ZnIgw5i1kCjlF5IklsBvteIpc5d23UoiPvY2v5wXb4vmnPY8LZM9KwWxZ5uou4McJhHfdnnECvPCuqToTbrc_8xeHt3_zfWHWL3DChNR1oXVgna2m-Qa7rc0mq2602yLoxZhXdMYjbz2-TfFIXiFMxo9V5iSdMFa3Rh4MO4GEineewKzaTUan7aRCFlpoRR3QRl3NFla5ZRKIakUvy2QsKOkgn08ExbUB8KWJiFKB4d8iHC-HDXdLLQQg2CYX4mKss9RLfV1xJFXMnhRRdhirzbKXCPmGtfETSoLTjsJCzqPn1KCBb09yMUKoiI1V9Yq2uKjVKyV_ot1H0It1ruzJy0QCSe8gQIM3tk8cNBUKE5FiDNIuXVRUN35_8A9HkuEP0zBBlBbyJjE3fBzwOQo91KLc6lPCRZWd5ExWlfaEq-inncGWrCb9ffrRaxk2xrjBPi6WmQUxMDowXHaVb8RHx17sr-fxzg8MeQpDBvPDen2--Ta4eTN-NotFwfHifXHOxfaYZQbJFevVimT4gV-TXel4tHjbGhJJPF62SPwDMPLY1
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1fa9RAEF_qKSKI2qr0tNpVFPUhvSSbZBNB5LAeHi3n0aul-BI3u9nzoCTxklP61fx0ziSb04CoL33weSebZDJ_NzO_IeRJ4isRBNK2XMaE5SnlWEkIihcxIaIg8jmvAUxPDvlkEp6eRtMN8r3thcGyytYm1oZa5RLPyAcuZFO1ewkG2pRFTPdHr4svFk6Qwj-t7TiNRkQO0vNvkL6Vr8b78K2fuu7o7fGbd5aZMGDJwGaVpZnPEsd1tMs83-WhVomWXig9W6QsSMMEwg0tleapp5iteRR5TLAEnKTyeZLYDPa9RC5zyDGxnHDqf2y9ANiRIDCteow7AyMZe0WepXuIIcMd1nGFxiH0irO87ES73VrNX5zf6Ob_zLZb5IYJuemw0ZFNspFmW-R6c15JmzasLbJpjFxJnxsk7he3STarcsSvmNPyvMCTp5JW6NtBN_CQkS4y2BWbzKhs-mwQnZaa0Ud0KYqFoqqpZUSiChFNsvlLCrpJZ8fDI1qD-1LEyshBIe-QDxfCh7ukl4FAbBMKcbOndOonQaA8JZXwnBRSdxkp7dtKRX3CWlmJpUFvxyEiZ3H9S5JDFtdwM0YJi42E9Ym1vqpo0Ev-Qr-LYhg3Pbhr4xcPIemHzAHS3z55XFMgdEiG0jQXq7KMx-9P_oFodtQhemaIdA5vIoXpB4HHQUiyDuVOhxI-suwsb6PStC9Uxj9lHq5steL3y4_Wy7gp1htmab5qaBAr0wPG844CrvmIuOzdlWzxucZnjyD4YH5078833yVXQRPjw_Hk4D655mJXTT2ZZIf0quUqfUCuyK_Volw-rO0KJZ8uWiN_ALmpvv8
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Stopping+syphilis+transmission+in+Arctic+communities+through+rapid+diagnostic+testing%3A+The+STAR+study+protocol&rft.jtitle=PloS+one&rft.au=Caya%2C+Chelsea&rft.au=Maheu-Giroux%2C+Mathieu&rft.au=Xia%2C+Yiqing&rft.au=Serhir%2C+Bouchra&rft.date=2022-09-12&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=17&rft.issue=9&rft.spage=e0273713&rft_id=info:doi/10.1371%2Fjournal.pone.0273713&rft.externalDBID=n%2Fa&rft.externalDocID=10_1371_journal_pone_0273713
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon