Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

Background Previous studies have developed models predicting methylation age from DNA methylation in blood and other tissues (epigenetic clock) and suggested the difference between DNA methylation and chronological ages as a marker of healthy aging. The goal of this study was to confirm and expand s...

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Vydáno v:	Clinical epigenetics Ročník 8; číslo 1; s. 64
Hlavní autoři:	Perna, Laura, Zhang, Yan, Mons, Ute, Holleczek, Bernd, Saum, Kai-Uwe, Brenner, Hermann
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 03.06.2016 BioMed Central Ltd Springer Nature B.V
Témata:	Aged Aging Aging (Biology) Aging - genetics Biomedical and Life Sciences Biomedicine Biorhythms Blood - metabolism Cardiovascular Diseases - genetics Cause of Death Cohort Studies development Disease susceptibility Epigenesis, Genetic Epigenetic inheritance Female Gene Function Genetic aspects Health aspects Human Genetics Humans imprinting and reproductive epigenetics Leukocyte Count Male Middle Aged Mortality Neoplasms - genetics Proportional Hazards Models Risk Factors Germany Epigenetic clock DNA methylation age Mortality risk Epigenetic age acceleration
ISSN:	1868-7075, 1868-7083, 1868-7083, 1868-7075
On-line přístup:	Získat plný text
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