Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment

Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause metastatic or complicated infections such as infective endocarditis or sepsis. MRSA is respo...

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Vydáno v:	Critical care (London, England) Ročník 21; číslo 1; s. 211 - 10
Hlavní autoři:	Hassoun, Ali, Linden, Peter K., Friedman, Bruce
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 14.08.2017 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Analysis Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Bacteremia Bacteremia - drug therapy Bacteremia - epidemiology Care and treatment Clinical outcomes Critical care Critical Care Medicine Diagnosis Diagnostic tests Emergency Medicine Epidemiology Gram-positive bacteria Health surveillance Hospitals Humans Incidence Intensive Intensive care Management Medicine Medicine & Public Health Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - pathogenicity Mortality MRSA MSSA Pathogens Penicillin Prevalence Prevalence studies (Epidemiology) Review Risk factors Staphylococcus aureus Staphylococcus infections United States > US Europe MSSA Prevalence MRSA Management Epidemiology Bacteremia Incidence Staphylococcus aureus
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X
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Shrnutí:	Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause metastatic or complicated infections such as infective endocarditis or sepsis. MRSA is responsible for most global S. aureus bacteremia cases, and compared with methicillin-sensitive S. aureus , MRSA infection is associated with poorer clinical outcomes. S. aureus virulence is affected by the unique combination of toxin and immune-modulatory gene products, which may differ by geographic location and healthcare- or community-associated acquisition. Management of S. aureus bacteremia involves timely identification of the infecting strain and source of infection, proper choice of antibiotic treatment, and robust prevention strategies. Resistance and nonsusceptibility to first-line antimicrobials combined with a lack of equally effective alternatives complicates MRSA bacteremia treatment. This review describes trends in epidemiology and factors that influence the incidence of MRSA bacteremia. Current and developing diagnostic tools, treatments, and prevention strategies are also discussed.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1364-8535 1466-609X 1364-8535 1466-609X 1366-609X
DOI:	10.1186/s13054-017-1801-3