Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment

Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause metastatic or complicated infections such as infective endocarditis or sepsis. MRSA is respo...

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Vydané v:Critical care (London, England) Ročník 21; číslo 1; s. 211 - 10
Hlavní autori: Hassoun, Ali, Linden, Peter K., Friedman, Bruce
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 14.08.2017
BioMed Central Ltd
Springer Nature B.V
BMC
Predmet:
Analysis
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobial agents
Bacteremia
Bacteremia - drug therapy
Bacteremia - epidemiology
Care and treatment
Clinical outcomes
Critical care
Critical Care Medicine
Diagnosis
Diagnostic tests
Emergency Medicine
Epidemiology
Gram-positive bacteria
Health surveillance
Hospitals
Humans
Incidence
Intensive
Intensive care
Management
Medicine
Medicine & Public Health
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - pathogenicity
Mortality
MRSA
MSSA
Pathogens
Penicillin
Prevalence
Prevalence studies (Epidemiology)
Review
Risk factors
Staphylococcus aureus
Staphylococcus infections
United States > US
Europe
MSSA
Prevalence
MRSA
Management
Epidemiology
Bacteremia
Incidence
Staphylococcus aureus
ISSN:1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X
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Popis
Shrnutí:Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of morbidity and mortality and can cause metastatic or complicated infections such as infective endocarditis or sepsis. MRSA is responsible for most global S. aureus bacteremia cases, and compared with methicillin-sensitive S. aureus , MRSA infection is associated with poorer clinical outcomes. S. aureus virulence is affected by the unique combination of toxin and immune-modulatory gene products, which may differ by geographic location and healthcare- or community-associated acquisition. Management of S. aureus bacteremia involves timely identification of the infecting strain and source of infection, proper choice of antibiotic treatment, and robust prevention strategies. Resistance and nonsusceptibility to first-line antimicrobials combined with a lack of equally effective alternatives complicates MRSA bacteremia treatment. This review describes trends in epidemiology and factors that influence the incidence of MRSA bacteremia. Current and developing diagnostic tools, treatments, and prevention strategies are also discussed.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ObjectType-Review-3
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ISSN:1364-8535
1466-609X
1364-8535
1466-609X
1366-609X
DOI:10.1186/s13054-017-1801-3