Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile

Background Rheumatoid arthritis (RA) is a multifactorial autoimmune disease, which is characterized by inflammation of synovial joints leading to the destruction of cartilage and bone. Infiltrating mast cells can be found within the inflamed synovial tissue, however their role in disease pathogenesi...

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Bibliographic Details
Published in:	Arthritis research & therapy Vol. 18; no. 1; p. 138
Main Authors:	van der Velden, Daniël, Lagraauw, H. Maxime, Wezel, Anouk, Launay, Pierre, Kuiper, Johan, Huizinga, Tom W. J., Toes, René E. M., Bot, Ilze, Stoop, Jeroen N.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 13.06.2016 BioMed Central Ltd Springer Nature B.V
Subjects:	Animals Arthritis Arthritis, Experimental - immunology Arthritis, Rheumatoid - immunology Care and treatment Clinical outcomes Collagen Cytokines Cytokines - biosynthesis Cytokines - immunology Development and progression Enzyme-Linked Immunosorbent Assay Flow Cytometry Genetic aspects Inflammation - immunology Mast cells Mast Cells - immunology Medicine Medicine & Public Health Mice Mice, Inbred DBA Mice, Knockout Orthopedics Patient outcomes Physiological aspects Research Article Rheumatoid arthritis Rheumatology France Netherlands RMB mice Mast cells T cells Collagen-induced arthritis
ISSN:	1478-6362, 1478-6354, 1478-6362
Online Access:	Get full text
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