Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix through protease recruitment and enhances cell adhesion, migration and signaling...

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Bibliographic Details
Published in:	eLife Vol. 6
Main Authors:	van Veen, Michiel, Matas-Rico, Elisa, van de Wetering, Koen, Leyton-Puig, Daniela, Kedziora, Katarzyna M, De Lorenzi, Valentina, Stijf-Bultsma, Yvette, van den Broek, Bram, Jalink, Kees, Sidenius, Nicolai, Perrakis, Anastassis, Moolenaar, Wouter H
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 29.08.2017 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Subjects:	Analysis Animals Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Biology Cancer cells Cancer research Cell Adhesion Cell Biology Cell Line, Tumor Cell Proliferation Cell surface Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Clustered Regularly Interspaced Short Palindromic Repeats Down-regulation Enzymes Extracellular matrix Female Flow cytometry GDE3 Gene Expression Regulation, Neoplastic Gene Knockout Techniques - methods Glycerophosphodiester phosphodiesterase Glycosylphosphatidylinositol HEK293 Cells Humans Hydrolysis Integrins Isoenzymes - genetics Isoenzymes - metabolism Ligands Localization Medical research Mice Mice, Nude Microscopy Models, Molecular Motility Neoplasm Transplantation Phospholipase C Phospholipases Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism Physiology Proteases Proteins Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors Receptors, Urokinase Plasminogen Activator - genetics Receptors, Urokinase Plasminogen Activator - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Scientific equipment industry Signal Transduction Statistical analysis Thrombolytic drugs Tumor Burden Tumors U-Plasminogen activator Vitronectin Vitronectin - genetics Vitronectin - metabolism Xenografts United States cell biology signal transduction GDE3 cancer biology glycosylphosphatidylinositol human glycerophosphodiester phosphodiesterase
ISSN:	2050-084X, 2050-084X
Online Access:	Get full text
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