Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat

It is well established that the binding of pathogenic aquaporin-4 (AQP4)-specific autoantibodies to astrocytes may initiate a cascade of events culminating in the destruction of these cells and in the formation of large tissue-destructive lesions typical for patients with neuromyelitis optica spectr...

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 137; no. 3; pp. 467 - 485
Main Authors:	Hillebrand, Sophie, Schanda, Kathrin, Nigritinou, Magdalini, Tsymala, Irina, Böhm, Denise, Peschl, Patrick, Takai, Yoshiki, Fujihara, Kazuo, Nakashima, Ichiro, Misu, Tatsuro, Reindl, Markus, Lassmann, Hans, Bradl, Monika
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2019 Springer Springer Nature B.V
Subjects:	Animals Antibodies Aquaporin 4 Aquaporin 4 - immunology Aquaporins Astrocytes Autoantibodies Autoantibodies - immunology Autoantibodies - pharmacology Autoantigens - immunology Autoimmunity Blood vessels Central nervous system EDTA Lymphocytes T Medical research Medical schools Medicine Medicine & Public Health Monoclonal antibodies Neovascularization Neuromyelitis Neuromyelitis optica Neuromyelitis Optica - immunology Neurosciences Original Paper Pathology Physiological aspects Rats Rats, Inbred Lew Rats, Nude T cells Aquaporin-4-specific antibodies Neuromyelitis optica Aquaporin-4 Lesions T cells Kidney
ISSN:	0001-6322, 1432-0533, 1432-0533
Online Access:	Get full text
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