Somatic mutations in neurons during aging and neurodegeneration

The nervous system is composed of a large variety of neurons with a diverse array of morphological and functional properties. This heterogeneity is essential for the construction and maintenance of a distinct set of neural networks with unique characteristics. Accumulating evidence now indicates tha...

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 135; no. 6; pp. 811 - 826
Main Authors:	Verheijen, Bert M., Vermulst, Marc, van Leeuwen, Fred W.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2018 Springer Springer Nature B.V
Subjects:	Aging Aging - genetics Animals Genetic aspects Genomics Humans Hypothalamus Medicine Medicine & Public Health Mosaicism Mutation Nerve Degeneration - genetics Nervous system Neural networks Neurodegeneration Neurodegenerative Diseases - genetics Neurons Neurophysiology Neurosciences Pathology Physiological aspects Pituitary Pituitary (posterior) Population genetics Review Somatic mutations Neurodegeneration Neuronal development Aging Genome integrity Somatic brain mosaicism Neurological disorders
ISSN:	0001-6322, 1432-0533, 1432-0533
Online Access:	Get full text
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