Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study
Background In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and older, we investigated whether the serum levels of two proinflammatory factors, in...
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| Vydáno v: | Immunity & ageing Ročník 13; číslo 1; s. 21 |
|---|---|
| Hlavní autoři: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
BioMed Central
03.06.2016
BioMed Central Ltd Springer Nature B.V |
| Témata: | |
| ISSN: | 1742-4933, 1742-4933 |
| On-line přístup: | Získat plný text |
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| Shrnutí: | Background
In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and older, we investigated whether the serum levels of two proinflammatory factors, interleukin-6 (IL-6) and C-reactive protein (CRP), were associated with physical and cognitive performance, and could predict mortality in successfully aging elderly.
Results
IL-6 and CRP levels systematically increased in an age-dependent manner in the entire study group (IL-6:
n
= 3496 individuals,
p
< 0.001 and CRP:
n
= 3632,
p
= 0.003), and in the subgroup of successfully aging individuals who had never been diagnosed with cardiovascular disease, myocardial infarction, stroke, type 2 diabetes, or cancer, and had a Mini Mental State Examination (MMSE) score ≥24 and a Katz Activities of Daily Living (ADL) score ≥5 (IL-6:
n
= 1258,
p
< 0.001 and CRP:
n
= 1312,
p
< 0.001). In the subgroup of individuals suffering from aging-related diseases/disability, only IL-6 increased with age (IL-6:
n
= 2238, p < 0.001 and CRP:
n
= 2320,
p
= 0.249). IL-6 and CRP levels were lower in successfully aging individuals than in the remaining study participants (both
p
< 0.001). Higher IL-6 and CRP levels were associated with poorer physical performance (lower ADL score) and poorer cognitive performance (lower MMSE score) (both
p
< 0.001). This association remained significant after adjusting for age, gender, BMI, lipids, estimated glomerular filtration rate, and smoking status. Longer survival was associated with lower concentrations of IL-6 and CRP not only in individuals with aging-related diseases/disability (HR = 1.063 per each pg/mL, 95 % CI: 1.052-1.074,
p
< 0.001 and HR = 1.020 per each mg/L, 95 % CI: 1.015-1.025,
p
< 0.001, respectively) but also in the successfully aging subgroup (HR = 1.163 per each pg/mL, 95 % CI: 1.128-1.199,
p
< 0.001 and HR = 1.074 per each mg/L, 95 % CI: 1.047-1.100,
p
< 0.001, respectively). These associations remained significant after adjusting for age, gender, BMI, lipids and smoking status. The Kaplan-Meier survival curves showed similar results (all
p
< 0.001).
Conclusions
Both IL-6 and CRP levels were good predictors of physical and cognitive performance and the risk of mortality in both the entire elderly population and in successfully aging individuals. |
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| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ISSN: | 1742-4933 1742-4933 |
| DOI: | 10.1186/s12979-016-0076-x |