Lipidome alterations in human prefrontal cortex during development, aging, and cognitive disorders

Lipids are essential to brain functions, yet they remain largely unexplored. Here we investigated the lipidome composition of prefrontal cortex gray matter in 396 cognitively healthy individuals with ages spanning 100 years, as well as 67 adult individuals diagnosed with autism (ASD), schizophrenia...

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Veröffentlicht in:	Molecular psychiatry Jg. 25; H. 11; S. 2952 - 2969
Hauptverfasser:	Yu, Qianhui, He, Zhisong, Zubkov, Dmitry, Huang, Shuyun, Kurochkin, Ilia, Yang, Xiaode, Halene, Tobias, Willmitzer, Lothar, Giavalisco, Patrick, Akbarian, Schahram, Khaitovich, Philipp
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.11.2020
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Aging Aging - metabolism Autism Child Child, Preschool Cognition Cognitive ability Cognitive Dysfunction - metabolism Cortex (temporal) Down's syndrome Female Fluidity Genetic diversity Humans Infant Lipidomics Lipids Male Membrane fluidity Mental disorders Middle Aged Nonagenarian Prefrontal cortex Prefrontal Cortex - growth & development Prefrontal Cortex - metabolism Schizophrenia Substantia grisea Young Adult
ISSN:	1359-4184, 1476-5578, 1476-5578
Online-Zugang:	Volltext
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