Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

Objectives Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no approved therapies directly target this activated subset of macrophages. Method...

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Veröffentlicht in:	Arthritis research & therapy Jg. 21; H. 1; S. 143 - 14
Hauptverfasser:	Hu, Yingwen, Wang, Bingbing, Shen, Jiayin, Low, Stewart A., Putt, Karson S., Niessen, Hans W. M., Matteson, Eric L., Murphy, Linda, Ruppert, Clemens, Jansen, Gerrit, Oliver, Stephen J., Feng, Yang, Dimitrov, Dimiter S., Nickerson-Nutter, Cheryl, Low, Philip S.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London BioMed Central 07.06.2019 BioMed Central Ltd Springer Nature B.V BMC
Schlagworte:	Activated macrophages Adalimumab Anakinra Animals Antibodies Antibodies, Monoclonal - therapeutic use Arthritis Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Autoimmune disease Autoimmune diseases B cells Binding proteins Canakinumab Care and treatment Cells, Cultured Chronic obstructive lung disease Chronic obstructive pulmonary disease Colitis Crohn's disease Cytokines Cytokines - metabolism Cytotoxicity Dendritic cells Disease Disease Models, Animal Ethanol Fibrosis Folate Receptor 2 - immunology Folate receptor beta Folic acid Golimumab Granulocytes Health aspects Humans Immunity, Cellular Inflammation Inflammatory bowel disease Inflammatory disease Inflammatory diseases Lupus Lupus erythematosus Macrophage Activation Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - pathology Medicine Medicine & Public Health Mice Monoclonal antibodies Neutrophils Orthopedics Peritonitis Physiological aspects Pneumonia Psoriasis Pulmonary fibrosis Research Article Rheumatoid arthritis Rheumatoid factor Rheumatology Rilonacept Scleroderma Scleroderma (Disease) Systemic lupus erythematosus T cells Tocilizumab Tumor necrosis factor Ulcerative colitis Ustekinumab Vitamin B United States United States > US Chicago Illinois Autoimmune disease Activated macrophages Rheumatoid arthritis Folate receptor beta Inflammatory disease
ISSN:	1478-6362, 1478-6354, 1478-6362
Online-Zugang:	Volltext
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