Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

The adipocyte-derived hormone adiponectin signals from the fat storage depot to regulate metabolism in peripheral tissues. Inversely correlated with body fat levels, adiponectin reduction in obese individuals may play a causal role in the symptoms of metabolic syndrome. Adiponectin lowers serum gluc...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 121; no. 6; pp. 2518 - 2528
Main Authors:	Miller, Russell A., Chu, Qingwei, Le Lay, John, Scherer, Philipp E., Ahima, Rexford S., Kaestner, Klaus H., Foretz, Marc, Viollet, Benoit, Birnbaum, Morris J.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.06.2011
Subjects:	Adiponectin - pharmacology Adiponectin - physiology Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP-Activated Protein Kinases - deficiency AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - physiology Animals Biomedical research Blood Glucose - analysis Body fat Cardiovascular disease Dextrose Fasting - blood Fatty acids Gene Deletion Gene expression Gene Expression Regulation - drug effects Genetic research Gluconeogenesis - drug effects Gluconeogenesis - genetics Glucose Glucose Clamp Technique Hepatocytes - drug effects Hepatocytes - metabolism Insulin - blood Insulin resistance Kinases Liver Metabolic syndrome Mice Organ Specificity Oxidation Phosphorylation Physiological aspects Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Proteins Recombinant Fusion Proteins - physiology Ribonucleotides - pharmacology Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Trans-Activators - deficiency Trans-Activators - genetics Trans-Activators - physiology Transcription Factors Transcription, Genetic - drug effects
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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