Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever

► History of LCMV infections of primates (from mice to monkeys and man). ► Comparison of outcomes in murine and primate infections. ► Description of findings from LCMV-infected rhesus macaques. ► Utility of the model for testing host-response antivirals over virus-specific antivirals. Arenaviruses s...

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Vydané v:	Antiviral research Ročník 92; číslo 2; s. 125 - 138
Hlavní autori:	Zapata, Juan C., Pauza, C. David, Djavani, Mahmoud M., Rodas, Juan D., Moshkoff, Dmitry, Bryant, Joseph, Ateh, Eugene, Garcia, Cybele, Lukashevich, Igor S., Salvato, Maria S.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier B.V 01.11.2011 Elsevier
Predmet:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Arenaviridae Infections - pathology Arenaviruses Biological and medical sciences Disease Models, Animal Human viral diseases Humans Infectious diseases Lassa Fever - pathology Lassa fever and arenovirus diseases Lassa fever virus Lassa virus LCMV Lymphocytic choriomeningitis virus Lymphocytic choriomeningitis virus - pathogenicity Macaca mulatta Medical sciences Monkey models Pharmacology. Drug treatments Primates Rhesus macaques Tropical viral diseases Viral diseases Viral hemorrhagic fever ML29 LCMV sIL6R Lassa fever virus TACV LCMV-WE Rhesus macaques PICV Arenaviruses MOPV sc Monkey models AST/ALT VHF LCMV-ARM ig sTnfRI im Viral hemorrhagic fever iv IL-6 PMN ffu sTNFRII LASV pfu Hemorrhagic fever Monkey Macaca mulatta Lassa virus Arenavirus Virus Infection Vertebrata Lassa fever Mammalia Lymphocytic choriomeningitis virus Viral disease Animal Arbovirus disease Primates Simioidea Models Arenaviridae
ISSN:	0166-3542, 1872-9096, 1872-9096
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Shrnutí:	► History of LCMV infections of primates (from mice to monkeys and man). ► Comparison of outcomes in murine and primate infections. ► Description of findings from LCMV-infected rhesus macaques. ► Utility of the model for testing host-response antivirals over virus-specific antivirals. Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. LCMV is considerably more benign for human beings than Lassa virus, however certain strains, like the LCMV-WE strain, can cause severe disease when the virus is delivered as a high-dose inoculum. Here we describe a rhesus macaque model for Lassa fever that employs a virulent strain of LCMV. Since LASV must be studied within Biosafety Level-4 (BSL-4) facilities, the LCMV-infected macaque model has the advantage that it can be used at BSL-3. LCMV-induced disease is rarely as severe as other VHF, but it is similar in cases where vascular leakage leads to lethal systemic failure. The LCMV-infected macaque has been valuable for describing the course of disease with differing viral strains, doses and routes of infection. By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0166-3542 1872-9096 1872-9096
DOI:	10.1016/j.antiviral.2011.07.015