Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

Synthetic biology has significantly advanced the design of genetic devices that can reprogram cellular activities and provide novel treatment strategies for future gene- and cell-based therapies. However, many metabolic disorders are functionally linked while developing distinct diseases that are di...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 110; číslo 1; s. 141
Hlavní autoři:	Ye, Haifeng, Charpin-El Hamri, Ghislaine, Zwicky, Katharina, Christen, Matthias, Folcher, Marc, Fussenegger, Martin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 02.01.2013
Témata:	Animals Cyclic AMP Response Element-Binding Protein - metabolism Dose-Response Relationship, Drug Drug Design Gene Expression Regulation - drug effects Glucagon-Like Peptide 1 - metabolism Guanabenz - pharmacology Leptin - metabolism Metabolic Syndrome - drug therapy Mice Models, Molecular Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Transgenes - genetics
ISSN:	1091-6490, 1091-6490
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