Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

Synthetic biology has significantly advanced the design of genetic devices that can reprogram cellular activities and provide novel treatment strategies for future gene- and cell-based therapies. However, many metabolic disorders are functionally linked while developing distinct diseases that are di...

Full description

Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 110; no. 1; p. 141
Main Authors:	Ye, Haifeng, Charpin-El Hamri, Ghislaine, Zwicky, Katharina, Christen, Matthias, Folcher, Marc, Fussenegger, Martin
Format:	Journal Article
Language:	English
Published:	United States 02.01.2013
Subjects:	Animals Cyclic AMP Response Element-Binding Protein - metabolism Dose-Response Relationship, Drug Drug Design Gene Expression Regulation - drug effects Glucagon-Like Peptide 1 - metabolism Guanabenz - pharmacology Leptin - metabolism Metabolic Syndrome - drug therapy Mice Models, Molecular Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Transgenes - genetics
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!