Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

The gut microbiota interacts with the host via neuroimmune, neuroendocrine and neural pathways. These pathways are components of the brain-gut-microbiota axis and preclinical evidence suggests that the microbiota can recruit this bidirectional communication system to modulate brain development, func...

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Bibliographic Details
Published in:	Journal of psychiatric research Vol. 82; pp. 109 - 118
Main Authors:	Kelly, John R., Borre, Yuliya, O' Brien, Ciaran, Patterson, Elaine, El Aidy, Sahar, Deane, Jennifer, Kennedy, Paul J., Beers, Sasja, Scott, Karen, Moloney, Gerard, Hoban, Alan E., Scott, Lucinda, Fitzgerald, Patrick, Ross, Paul, Stanton, Catherine, Clarke, Gerard, Cryan, John F., Dinan, Timothy G.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.11.2016
Subjects:	Adult Aged Animals Brain-gut axis C-Reactive Protein - metabolism Case-Control Studies Corticosterone - blood Cytokines - blood Depression Depression - microbiology Depression - pathology Disease Models, Animal Feces - microbiology Female Food Preferences - physiology Gastrointestinal Microbiome - physiology Gastrointestinal Tract - microbiology Gut microbiota Humans Hydrocortisone - metabolism Inflammation Intestinal barrier Kynurenine - blood Lipopolysaccharides - blood Lipopolysaccharides - pharmacology Male Maze Learning - physiology Middle Aged Psychiatry Rats Rats, Sprague-Dawley RNA, Ribosomal, 16S - metabolism Tryptophan Gut microbiota Tryptophan Intestinal barrier Depression Inflammation Brain-gut axis
ISSN:	0022-3956, 1879-1379, 1879-1379
Online Access:	Get full text
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