Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease

The microbial metabolite Trimethylamine-N-oxide (TMAO) has been linked to adverse cardiovascular outcome and mortality in the general population. To assess the contribution of TMAO to inflammation and mortality in chronic kidney disease (CKD) patients ranging from mild-moderate to end-stage disease...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 1; p. e0141738
Main Authors:	Missailidis, Catharina, Hällqvist, Jenny, Qureshi, Abdel Rashid, Barany, Peter, Heimbürger, Olof, Lindholm, Bengt, Stenvinkel, Peter, Bergman, Peter
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 2016 Public Library of Science (PLoS)
Subjects:	Adult Aged Atherosclerosis Betaine Betaine - blood Biomarkers Biomarkers - blood C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - etiology Cardiovascular Diseases - mortality Choline Choline - blood Chromatography Correlation analysis Dialysis Female Fibrinogen Fibrinogen - metabolism Glomerular Filtration Rate Heart failure Hospitals Humans Inflammation Interleukin 6 Interleukin-6 - blood Kidney diseases Kidney Transplantation Kidneys Laboratories Liquid chromatography Longitudinal Studies Male Mass spectrometry Mass spectroscopy Medicine Metabolism Metabolites Methylamines - blood Microbiota Microorganisms Middle Aged Mortality Multivariate Analysis Nephrology Nutrition Nutritional status Patients Peritoneal dialysis Prognosis Renal Dialysis Renal function Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - mortality Science Severity of Illness Index Studies Survival Analysis Transplantation Trimethylamine Trimethylamine-N-oxide Urologi och njurmedicin Urology and Nephrology Sweden
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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