Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

Hepatitis B virus (HBV), the causative agent of chronic hepatitis B and prototypic hepadnavirus, is a small DNA virus that replicates by protein-primed reverse transcription. The product is a 3-kb relaxed circular DNA (RC-DNA) in which one strand is linked to the viral polymerase (P protein) through...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 40; p. E4244
Main Authors:	Königer, Christian, Wingert, Ida, Marsmann, Moritz, Rösler, Christine, Beck, Jürgen, Nassal, Michael
Format:	Journal Article
Language:	English
Published:	United States 07.10.2014
Subjects:	Animals Avian Proteins - genetics Avian Proteins - metabolism Base Sequence Cell Line, Tumor Chickens DNA Repair DNA, Circular - chemistry DNA, Circular - genetics DNA, Circular - metabolism DNA, Viral - chemistry DNA, Viral - genetics DNA, Viral - metabolism Hep G2 Cells Hepatitis B virus - genetics Hepatitis B virus - metabolism Hepatitis B Virus, Duck - genetics Hepatitis B Virus, Duck - metabolism Humans Immunoblotting Nuclear Proteins - genetics Nuclear Proteins - metabolism Nucleic Acid Conformation Phosphoric Diester Hydrolases - genetics Phosphoric Diester Hydrolases - metabolism RNA Interference Transcription Factors - genetics Transcription Factors - metabolism Virus Replication - genetics TDP substrate specificity hepatitis B virus persistence virus–DNA repair interface
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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