Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes

Chronic infections could be contributing to the socioeconomic gradient in chronic diseases. Although chronic infections have been associated with increased levels of inflammatory cytokines and cardiovascular disease, there is limited evidence on how infections affect risk of diabetes. We examined th...

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Vydáno v:	Diabetes care Ročník 35; číslo 3; s. 520 - 525
Hlavní autoři:	Jeon, Christie Y., Haan, Mary N., Cheng, Caroline, Clayton, Erin R., Mayeda, Elizabeth R., Miller, Joshua W., Aiello, Allison E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Alexandria, VA American Diabetes Association 01.03.2012
Témata:	Aged Aged, 80 and over antibiotics antibodies bacterial infections Biological and medical sciences blood C-reactive protein Cardiovascular diseases Cholesterol chronic diseases Cohort Studies Cytomegalovirus Cytomegalovirus Infections Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - physiopathology Diabetes Diabetes Mellitus Diabetes Mellitus - epidemiology Diabetes Mellitus - etiology Diabetes. Impaired glucose tolerance education elderly Endocrine pancreas. Apud cells (diseases) Endocrinopathies epidemiology etiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female gastrointestinal system Health aspects Helicobacter Infections Helicobacter Infections - epidemiology Helicobacter Infections - physiopathology Helicobacter pylori Helicobacter pylori - pathogenicity Herpes simplex virus 1 Hispanic Americans Human alphaherpesvirus 1 Humans Insulin resistance interleukin-6 Latinos Male Medical research Medical sciences Medicine, Experimental Metabolic diseases Middle Aged Miscellaneous Original Research pathogenicity physiopathology Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine risk seroprevalence Socioeconomic factors Studies Toxoplasma gondii Varicella-zoster virus viruses California Endocrinopathy Human Spirillales Nutrition Diabetes mellitus Rate Spirillaceae Metabolic diseases Infection Association Helicobacter pylori Bacteriosis Bacteria Endocrinology
ISSN:	0149-5992, 1935-5548, 1935-5548
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Chronic infections could be contributing to the socioeconomic gradient in chronic diseases. Although chronic infections have been associated with increased levels of inflammatory cytokines and cardiovascular disease, there is limited evidence on how infections affect risk of diabetes. We examined the association between serological evidence of chronic viral and bacterial infections and incident diabetes in a prospective cohort of Latino elderly. We analyzed data on 782 individuals aged >60 years and diabetes-free in 1998-1999, whose blood was tested for antibodies to herpes simplex virus 1, varicella virus, cytomegalovirus, Helicobacter pylori, and Toxoplasma gondii and who were followed until June 2008. We used Cox proportional hazards regression to estimate the relative incidence rate of diabetes by serostatus, with adjustment for age, sex, education, cardiovascular disease, smoking, and cholesterol levels. Individuals seropositive for herpes simplex virus 1, varicella virus, cytomegalovirus, and T. gondii did not show an increased rate of diabetes, whereas those who were seropositive for H. pylori at enrollment were 2.7 times more likely at any given time to develop diabetes than seronegative individuals (hazard ratio 2.69 [95% CI 1.10-6.60]). Controlling for insulin resistance, C-reactive protein and interleukin-6 did not attenuate the effect of H. pylori infection. We demonstrated for the first time that H. pylori infection leads to an increased rate of incident diabetes in a prospective cohort study. Our findings implicate a potential role for antibiotic and gastrointestinal treatment in preventing diabetes.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0149-5992 1935-5548 1935-5548
DOI:	10.2337/dc11-1043