Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

The development of clonal hematopoiesis with increasing age was associated with nearly a doubling in the risk of coronary heart disease, along with an increase in coronary calcifications, possibly due to heightened production of inflammatory markers.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 377; no. 2; pp. 111 - 121
Main Authors: Jaiswal, Siddhartha, Natarajan, Pradeep, Silver, Alexander J, Gibson, Christopher J, Bick, Alexander G, Shvartz, Eugenia, McConkey, Marie, Gupta, Namrata, Gabriel, Stacey, Ardissino, Diego, Baber, Usman, Mehran, Roxana, Fuster, Valentin, Danesh, John, Frossard, Philippe, Saleheen, Danish, Melander, Olle, Sukhova, Galina K, Neuberg, Donna, Libby, Peter, Kathiresan, Sekar, Ebert, Benjamin L
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 13.07.2017
Subjects:
Age
Animals
Aorta
Arteriosclerosis
Atherosclerosis
Atherosclerosis - genetics
Blood cancer
Blood cells
Bone marrow
Calcification (ectopic)
Cancer
Cardiology
Cardiology and Cardiovascular Disease
Cardiovascular disease
Cardiovascular diseases
Case-Control Studies
Clinical Medicine
Clonal Evolution
Coronary artery disease
Coronary Disease - genetics
Coronary vessels
Exome
Genes
Genetic Predisposition to Disease
Genomics
Heart diseases
Hematology
Hematopoiesis - genetics
Hematopoietic Stem Cells
Humans
Hypercholesterolemia
Janus kinase 2
Kardiologi och kardiovaskulära sjukdomar
Klinisk medicin
Lipoproteins
Macrophages
Medical and Health Sciences
Medicin och hälsovetenskap
Mice
Mice, Knockout
Mutation
Myocardial infarction
Peripheral blood
Risk
Sequence Analysis, DNA - methods
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:The development of clonal hematopoiesis with increasing age was associated with nearly a doubling in the risk of coronary heart disease, along with an increase in coronary calcifications, possibly due to heightened production of inflammatory markers.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1701719