A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1

Hongbing Shen, Dongxin Lin, Yongyong Shi and colleagues identify two new susceptibility loci for non-cardia gastric cancer. They also confirm three previously reported risk loci for this gastric cancer subtype. Gastric cancer, including the cardia and non-cardia types, is the second leading cause of...

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Veröffentlicht in:Nature genetics Jg. 43; H. 12; S. 1215 - 1218
Hauptverfasser: Shi, Yongyong, Hu, Zhibin, Wu, Chen, Dai, Juncheng, Li, Huizhang, Dong, Jing, Wang, Meilin, Miao, Xiaoping, Zhou, Yifeng, Lu, Feng, Zhang, Hanze, Hu, Lingmin, Jiang, Yue, Li, Zhiqiang, Chu, Minjie, Ma, Hongxia, Chen, Jiaping, Jin, Guangfu, Tan, Wen, Wu, Tangchun, Zhang, Zhengdong, Lin, Dongxin, Shen, Hongbing
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Nature Publishing Group US 01.12.2011
Nature Publishing Group
Schlagworte:
631/208/205/2138
631/208/727/2000
631/67/2324
692/699/67/1504/1829
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Agriculture
AMP-Activated Protein Kinases - genetics
Animal Genetics and Genomics
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Chromosomes, Human, Pair 3 - genetics
Chromosomes, Human, Pair 5 - genetics
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Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
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Genetic aspects
Genetic Loci
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
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Nerve Tissue Proteins - genetics
Odds Ratio
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Polymorphism, Single Nucleotide
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Receptors, Prostaglandin E, EP4 Subtype - genetics
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Stomach cancer
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Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Transcription Factors - genetics
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China
Digestive diseases
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Malignant tumor
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Stomach cancer
Cancer
Gastric disease
ISSN:1061-4036, 1546-1718, 1546-1718
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Zusammenfassung:Hongbing Shen, Dongxin Lin, Yongyong Shi and colleagues identify two new susceptibility loci for non-cardia gastric cancer. They also confirm three previously reported risk loci for this gastric cancer subtype. Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1 ; odds ratio (OR) = 1.41; P = 7.6 × 10 −29 ) and 3q13.31 (rs9841504 in ZBTB20 ; OR = 0.76; P = 1.7 × 10 −9 ). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
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ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/ng.978