Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes

OBJECTIVE: A loss of skeletal muscle mass is frequently observed in older adults. The aim of the study was to investigate the impact of type 2 diabetes on the changes in body composition, with particular interest in the skeletal muscle mass. RESEARCH DESIGN AND METHODS: We examined total body compos...

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Vydáno v:	Diabetes care Ročník 32; číslo 11; s. 1993 - 1997
Hlavní autoři:	Park, Seok Won, Goodpaster, Bret H, Lee, Jung Sun, Kuller, Lewis H, Boudreau, Robert, de Rekeneire, Nathalie, Harris, Tamara B, Kritchevsky, Stephen, Tylavsky, Frances A, Nevitt, Michael, Cho, Yong-wook, Newman, Anne B
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Alexandria, VA American Diabetes Association 01.11.2009
Témata:	Absorptiometry, Photon Adipose Tissue Adipose Tissue - anatomy & histology Age Aged Aging Aging - physiology anatomy & histology Biological and medical sciences blood blood glucose Blood Glucose - metabolism Body Composition Body fat Body Mass Index Body Weight computed tomography Dextrose Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 - diagnostic imaging Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance dual-energy X-ray absorptiometry elderly Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme-Linked Immunosorbent Assay Etiopathogenesis. Screening. Investigations. Target tissue resistance fasting Female Glucose Glucose Tolerance Test Humans Hypoglycemic agents Hypoglycemic Agents - therapeutic use Interleukin-6 Interleukin-6 - blood Male Medical sciences Metabolic diseases metabolism Middle Aged Miscellaneous Mortality Muscle, Skeletal Muscle, Skeletal - anatomy & histology Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - pathology Muscular system noninsulin-dependent diabetes mellitus Nutrition Older people Organ Size Original Research pathology Physiological aspects physiology physiopathology Public health. Hygiene Public health. Hygiene-occupational medicine radiography Regression Analysis risk Risk factors skeletal muscle Studies therapeutic use Tomography Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha - blood Type 2 diabetes Variables women Endocrinopathy Human Type 2 diabetes Mass Nutrition Loss Metabolic diseases Striated muscle Elderly Endocrinology
ISSN:	0149-5992, 1935-5548, 1935-5548
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Shrnutí:	OBJECTIVE: A loss of skeletal muscle mass is frequently observed in older adults. The aim of the study was to investigate the impact of type 2 diabetes on the changes in body composition, with particular interest in the skeletal muscle mass. RESEARCH DESIGN AND METHODS: We examined total body composition with dual-energy X-ray absorptiometry annually for 6 years in 2,675 older adults. We also measured mid-thigh muscle cross-sectional area (CSA) with computed tomography in year 1 and year 6. At baseline, 75-g oral glucose challenge tests were performed. Diagnosed diabetes (n = 402, 15.0%) was identified by self-report or use of hypoglycemic agents. Undiagnosed diabetes (n = 226, 8.4%) was defined by fasting plasma glucose (greater-than-or-equal7 mmol/l) or 2-h postchallenge plasma glucose (greater-than-or-equal11.1 mmol/l). Longitudinal regression models were fit to examine the effect of diabetes on the changes in body composition variables. RESULTS: Older adults with either diagnosed or undiagnosed type 2 diabetes showed excessive loss of appendicular lean mass and trunk fat mass compared with nondiabetic subjects. Thigh muscle CSA declined two times faster in older women with diabetes than their nondiabetic counterparts. These findings remained significant after adjusting for age, sex, race, clinic site, baseline BMI, weight change intention, and actual weight changes over time. CONCLUSIONS: Type 2 diabetes is associated with excessive loss of skeletal muscle and trunk fat mass in community-dwelling older adults. Older women with type 2 diabetes are at especially high risk for loss of skeletal muscle mass.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0149-5992 1935-5548 1935-5548
DOI:	10.2337/dc09-0264