Three Indonesian Clusters of H5N1 Virus Infection in 2005

In 2005, multiple cases of avian influenza A (H5N1) virus infection were identified in Indonesia. Three case clusters are reported, involving eight patients with a 50% rate of death, although mild disease was also seen. The outbreak was caused by clade 2 H5N1 virus, and no antiviral resistance was i...

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Published in:The New England journal of medicine Vol. 355; no. 21; pp. 2186 - 2194
Main Authors: Kandun, I. Nyoman, Wibisono, Hariadi, Sedyaningsih, Endang R, Yusharmen, Hadisoedarsuno, Widarso, Purba, Wilfried, Santoso, Hari, Septiawati, Chita, Tresnaningsih, Erna, Heriyanto, Bambang, Yuwono, Djoko, Harun, Syahrial, Soeroso, Santoso, Giriputra, Sardikin, Blair, Patrick J, Jeremijenko, Andrew, Kosasih, Herman, Putnam, Shannon D, Samaan, Gina, Silitonga, Marlinggom, Chan, K.H, Poon, Leo L.M, Lim, Wilina, Klimov, Alexander, Lindstrom, Stephen, Guan, Yi, Donis, Ruben, Katz, Jacqueline, Cox, Nancy, Peiris, Malik, Uyeki, Timothy M
Format: Journal Article
Language:English
Published: Boston, MA Massachusetts Medical Society 23.11.2006
Subjects:
Adult
Animals
Antiviral Agents - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Disease Outbreaks
Female
Fever
General aspects
Human viral diseases
Humans
Illnesses
Indonesia - epidemiology
Infant
Infectious diseases
Influenza A Virus, H5N1 Subtype - genetics
Influenza A Virus, H5N1 Subtype - isolation & purification
Influenza, Human - epidemiology
Influenza, Human - therapy
Laboratories
Male
Medical sciences
Oseltamivir - therapeutic use
Patients
Public health
Respiration, Artificial
Shipments
Ventilation
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Asia
Indonesia
Infection
Medicine
Avian influenza
Influenzavirus A(H5N1)
2005
Viral disease
Public health
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:In 2005, multiple cases of avian influenza A (H5N1) virus infection were identified in Indonesia. Three case clusters are reported, involving eight patients with a 50% rate of death, although mild disease was also seen. The outbreak was caused by clade 2 H5N1 virus, and no antiviral resistance was identified. In 2005, multiple cases of avian influenza A (H5N1) virus infection were identified in Indonesia. Three case clusters are reported. The outbreak was caused by clade 2 H5N1 virus, and no antiviral resistance was identified. The avian influenza A (H5N1) epizootic has resulted in sporadic human cases and case clusters. Previously, H5N1 case clustering was observed in cousins in 1997 1 and in a father and son in 2003. 2 H5N1 clustering was described in 2004–2005 but without sufficient information to assess whether human-to-human transmission had occurred. 3 Although only one likely instance of limited human-to-human transmission of H5N1 virus was detailed in Thailand in 2004, 4 the investigation of case clusters is critically important, since an increase in clusters could suggest greater transmissibility of H5N1 viruses. Since 2003, H5N1 outbreaks in poultry have occurred throughout Indonesia. 5 – 7 Indonesia's . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa060930