Three Indonesian Clusters of H5N1 Virus Infection in 2005

In 2005, multiple cases of avian influenza A (H5N1) virus infection were identified in Indonesia. Three case clusters are reported, involving eight patients with a 50% rate of death, although mild disease was also seen. The outbreak was caused by clade 2 H5N1 virus, and no antiviral resistance was i...

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Vydané v:	The New England journal of medicine Ročník 355; číslo 21; s. 2186 - 2194
Hlavní autori:	Kandun, I. Nyoman, Wibisono, Hariadi, Sedyaningsih, Endang R, Yusharmen, Hadisoedarsuno, Widarso, Purba, Wilfried, Santoso, Hari, Septiawati, Chita, Tresnaningsih, Erna, Heriyanto, Bambang, Yuwono, Djoko, Harun, Syahrial, Soeroso, Santoso, Giriputra, Sardikin, Blair, Patrick J, Jeremijenko, Andrew, Kosasih, Herman, Putnam, Shannon D, Samaan, Gina, Silitonga, Marlinggom, Chan, K.H, Poon, Leo L.M, Lim, Wilina, Klimov, Alexander, Lindstrom, Stephen, Guan, Yi, Donis, Ruben, Katz, Jacqueline, Cox, Nancy, Peiris, Malik, Uyeki, Timothy M
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Boston, MA Massachusetts Medical Society 23.11.2006
Predmet:	Adult Animals Antiviral Agents - therapeutic use Biological and medical sciences Child Child, Preschool Disease Outbreaks Female Fever General aspects Human viral diseases Humans Illnesses Indonesia - epidemiology Infant Infectious diseases Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - isolation & purification Influenza, Human - epidemiology Influenza, Human - therapy Laboratories Male Medical sciences Oseltamivir - therapeutic use Patients Public health Respiration, Artificial Shipments Ventilation Viral diseases Viral diseases of the respiratory system and ent viral diseases Asia Indonesia Infection Medicine Avian influenza Influenzavirus A(H5N1) 2005 Viral disease Public health
ISSN:	0028-4793, 1533-4406, 1533-4406
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Shrnutí:	In 2005, multiple cases of avian influenza A (H5N1) virus infection were identified in Indonesia. Three case clusters are reported, involving eight patients with a 50% rate of death, although mild disease was also seen. The outbreak was caused by clade 2 H5N1 virus, and no antiviral resistance was identified. In 2005, multiple cases of avian influenza A (H5N1) virus infection were identified in Indonesia. Three case clusters are reported. The outbreak was caused by clade 2 H5N1 virus, and no antiviral resistance was identified. The avian influenza A (H5N1) epizootic has resulted in sporadic human cases and case clusters. Previously, H5N1 case clustering was observed in cousins in 1997 1 and in a father and son in 2003. 2 H5N1 clustering was described in 2004–2005 but without sufficient information to assess whether human-to-human transmission had occurred. 3 Although only one likely instance of limited human-to-human transmission of H5N1 virus was detailed in Thailand in 2004, 4 the investigation of case clusters is critically important, since an increase in clusters could suggest greater transmissibility of H5N1 viruses. Since 2003, H5N1 outbreaks in poultry have occurred throughout Indonesia. 5 – 7 Indonesia's . . .
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Feature-3 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa060930