Recent advances in the genetic basis of taste detection in Drosophila

The insect gustatory system senses taste information from environmental food substrates and processes it to control feeding behaviors. Drosophila melanogaster has been a powerful genetic model for investigating how various chemical cues are detected at the molecular and cellular levels. In addition...

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Vydané v:	Cellular and molecular life sciences : CMLS Ročník 77; číslo 6; s. 1087 - 1101
Hlavní autori:	Chen, Yu-Chieh David, Dahanukar, Anupama
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Cham Springer International Publishing 01.03.2020 Springer Nature B.V
Predmet:	Amino acids Ammonia Animals Biochemistry Biomedical and Life Sciences Biomedicine Bitter taste Calcium Carbonation Cell Biology Chemical stimuli Chemoreception Drosophila - anatomy & histology Drosophila - cytology Drosophila - genetics Drosophila - physiology Drosophila melanogaster Drosophila Proteins - analysis Drosophila Proteins - genetics Drosophila Proteins - metabolism Fatty acids Feeding behavior Food processing Fruit flies Functionals Gene Expression genetic models Gustatory system Hydrogen peroxide Information systems insect behavior insect pests Insects Life Sciences Lipopolysaccharides Neural coding Neurons Organs Pest control Polyamines Receptors Receptors, Cell Surface - analysis Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Review Sensory neurons Sensory Receptor Cells - cytology Sensory Receptor Cells - metabolism Substrates Sweet taste Taste Taste receptors gustation Taste Feeding behavior Chemosensory receptors Drosophila gustation
ISSN:	1420-682X, 1420-9071, 1420-9071
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Shrnutí:	The insect gustatory system senses taste information from environmental food substrates and processes it to control feeding behaviors. Drosophila melanogaster has been a powerful genetic model for investigating how various chemical cues are detected at the molecular and cellular levels. In addition to an understanding of how tastants belonging to five historically described taste modalities (sweet, bitter, acid, salt, and amino acid) are sensed, recent findings have identified taste neurons and receptors that recognize tastants of non-canonical modalities, including fatty acids, carbonated water, polyamines, H 2 O 2 , bacterial lipopolysaccharide (LPS), ammonia, and calcium. Analyses of response profiles of taste neurons expressing different suites of chemosensory receptors have allowed exploration of taste coding mechanisms in primary sensory neurons. In this review, we present the current knowledge of the molecular and cellular basis of taste detection of various categories of tastants. We also summarize evidence for organotopic and multimodal functions of the taste system. Functional characterization of peripheral taste neurons in different organs has greatly increased our understanding of how insect behavior is regulated by the gustatory system, which may inform development of novel insect pest control strategies.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Conceptualization, Y.-C.D.C. and A.D.; Writing – Original Draft, Y.-C.D.C., Writing – Review & Editing, Y.-C.D.C. and A.D.; Supervision, A.D.; Funding Acquisition, A.D. Author Contributions
ISSN:	1420-682X 1420-9071 1420-9071
DOI:	10.1007/s00018-019-03320-0