Pathogenicity and virulence of Staphylococcus aureus

Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of S. aureus infections is complicated...

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Published in:Virulence Vol. 12; no. 1; pp. 547 - 569
Main Authors: Cheung, Gordon Y. C., Bae, Justin S., Otto, Michael
Format: Journal Article
Language:English
Published: United States Taylor & Francis 01.12.2021
Taylor & Francis Group
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
biofilm
Humans
immune evasion
infection
Methicillin-Resistant Staphylococcus aureus - pathogenicity
Mice
mrsa
neutrophils
Quorum Sensing
Review
Sepsis
Staphylococcal Infections - drug therapy
Staphylococcal Infections - immunology
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Staphylococcus aureus - pathogenicity
toxins
Virulence
Virulence Factors - genetics
mrsa
infection
immune evasion
quorum-sensing
virulence
biofilm
toxins
neutrophils
Staphylococcus aureus
ISSN:2150-5594, 2150-5608, 2150-5608
Online Access:Get full text
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Summary:Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of S. aureus infections is complicated by antibiotic resistance and a working vaccine is not available. There has been ongoing and increasing interest in the extraordinarily high number of toxins and other virulence determinants that S. aureus produces and how they impact disease. In this review, we will give an overview of how S. aureus initiates and maintains infection and discuss the main determinants involved. A more in-depth understanding of the function and contribution of S. aureus virulence determinants to S. aureus infection will enable us to develop anti-virulence strategies to counteract the lack of an anti-S. aureus vaccine and the ever-increasing shortage of working antibiotics against this important pathogen.
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ISSN:2150-5594
2150-5608
2150-5608
DOI:10.1080/21505594.2021.1878688