Anti-HBs positive occult hepatitis B virus carrier blood infectious in two transfusion recipients

Occult hepatitis B infection (OBI) in blood donations is not considered infectious when anti-HBs is present. Four months after transfusion of eight blood components during coronary arterial bypass surgery, a 59-year-old patient developed acute hepatitis B. A second 71-year-old patient transfused wit...

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Veröffentlicht in:Journal of hepatology Jg. 48; H. 6; S. 1022 - 1025
Hauptverfasser: Levicnik-Stezinar, Snezna, Rahne-Potokar, Urska, Candotti, Daniel, Lelie, Nico, Allain, Jean-Pierre
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Oxford Elsevier B.V 01.06.2008
Elsevier
Schlagworte:
Aged
Antibodies, Viral - blood
Biological and medical sciences
Blood transfusion
DNA, Viral - blood
Female
Gastroenterology and Hepatology
Gastroenterology. Liver. Pancreas. Abdomen
HBV
Hepatitis B - blood
Hepatitis B - diagnosis
Hepatitis B - transmission
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Humans
Infectivity
Male
Medical sciences
Middle Aged
Occult HBV
Transfusion Reaction
anti-HBc
anti-HBs
FFP
Occult HBV
RCC
BCP/PC
Infectivity
OBI
QPCR
HBV
Blood transfusion
hepatitis B virus
real-time PCR
antibody to hepatitis B virus core antigen
basic core promoter/pre-core
fresh frozen plasma
red cell concentrate
antibody to hepatitis B virus surface antigen
occult HBV infection
Human
Transfusion
Orthohepadnavirus
Recipient
Blood
Virus
Infection
Hepadnaviridae
Gastroenterology
Hepatitis B virus
ISSN:0168-8278, 1600-0641
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Zusammenfassung:Occult hepatitis B infection (OBI) in blood donations is not considered infectious when anti-HBs is present. Four months after transfusion of eight blood components during coronary arterial bypass surgery, a 59-year-old patient developed acute hepatitis B. A second 71-year-old patient transfused with a red cell concentrate (RCC) from one of these donations had early HBV infection 7months post-transfusion. Samples were tested for HBV serological markers and HBV DNA was quantified and sequenced. One implicated donation contained anti-HBc, anti-HBs (12 IU/L) and 180IU/ml of HBV DNA. Previous and subsequent samples contained 3–10 times lower viral load and slightly variable anti-HBs. Two previous donations did not cause HBV infection. Recipients of the FFP and RCC from the index donation were both HBV infected and carried genotype D strains with sequences identical to the donor strain. Despite anti-HBs, an OBI carrier transmitted HBV to two immunocompetent transfusion recipients.
Bibliographie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2008.02.016