C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis

Transcription-factor-induced somatic cell conversions are highly relevant for both basic and clinical research yet their mechanism is not fully understood and it is unclear whether they reflect normal differentiation processes. Here we show that during pre-B-cell-to-macrophage transdifferentiation,...

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Veröffentlicht in:	Stem cell reports Jg. 5; H. 2; S. 232 - 247
Hauptverfasser:	van Oevelen, Chris, Collombet, Samuel, Vicent, Guillermo, Hoogenkamp, Maarten, Lepoivre, Cyrille, Badeaux, Aimee, Bussmann, Lars, Sardina, Jose Luis, Thieffry, Denis, Beato, Miguel, Shi, Yang, Bonifer, Constanze, Graf, Thomas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 11.08.2015 Elsevier
Schlagworte:	B-Lymphocytes - cytology B-Lymphocytes - metabolism CCAAT-Enhancer-Binding Protein-alpha - genetics CCAAT-Enhancer-Binding Protein-alpha - metabolism Cell Line Cell Transdifferentiation Humans Myeloid Cells - cytology Myeloid Cells - metabolism Myelopoiesis Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism
ISSN:	2213-6711, 2213-6711
Online-Zugang:	Volltext
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