Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke

Despite many years of research, no biomarkers for stroke are available to use in clinical practice. Progress in high-throughput technologies has provided new opportunities to understand the pathophysiology of this complex disease, and these studies have generated large amounts of data and informatio...

Full description

Saved in:
Bibliographic Details
Published in:Nature reviews. Neurology Vol. 16; no. 5; pp. 247 - 264
Main Authors: Montaner, Joan, Ramiro, Laura, Simats, Alba, Tiedt, Steffen, Makris, Konstantinos, Jickling, Glen C, Debette, Stephanie, Sanchez, Jean-Charles, Bustamante, Alejandro
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.05.2020
Subjects:
Biomarkers
Genomics
Proteomics
ISSN:1759-4758, 1759-4766, 1759-4766
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Despite many years of research, no biomarkers for stroke are available to use in clinical practice. Progress in high-throughput technologies has provided new opportunities to understand the pathophysiology of this complex disease, and these studies have generated large amounts of data and information at different molecular levels. The integration of these multi-omics data means that thousands of proteins (proteomics), genes (genomics), RNAs (transcriptomics) and metabolites (metabolomics) can be studied simultaneously, revealing interaction networks between the molecular levels. Integrated analysis of multi-omics data will provide useful insight into stroke pathogenesis, identification of therapeutic targets and biomarker discovery. In this Review, we detail current knowledge on the pathology of stroke and the current status of biomarker research in stroke. We summarize how proteomics, metabolomics, transcriptomics and genomics are all contributing to the identification of new candidate biomarkers that could be developed and used in clinical stroke management.
AbstractList Despite many years of research, no biomarkers for stroke are available to use in clinical practice. Progress in high-throughput technologies has provided new opportunities to understand the pathophysiology of this complex disease, and these studies have generated large amounts of data and information at different molecular levels. The integration of these multi-omics data means that thousands of proteins (proteomics), genes (genomics), RNAs (transcriptomics) and metabolites (metabolomics) can be studied simultaneously, revealing interaction networks between the molecular levels. Integrated analysis of multi-omics data will provide useful insight into stroke pathogenesis, identification of therapeutic targets and biomarker discovery. In this Review, we detail current knowledge on the pathology of stroke and the current status of biomarker research in stroke. We summarize how proteomics, metabolomics, transcriptomics and genomics are all contributing to the identification of new candidate biomarkers that could be developed and used in clinical stroke management.
Despite many years of research, no biomarkers for stroke are available to use in clinical practice. Progress in high-throughput technologies has provided new opportunities to understand the pathophysiology of this complex disease, and these studies have generated large amounts of data and information at different molecular levels. The integration of these multi-omics data means that thousands of proteins (proteomics), genes (genomics), RNAs (transcriptomics) and metabolites (metabolomics) can be studied simultaneously, revealing interaction networks between the molecular levels. Integrated analysis of multi-omics data will provide useful insight into stroke pathogenesis, identification of therapeutic targets and biomarker discovery. In this Review, we detail current knowledge on the pathology of stroke and the current status of biomarker research in stroke. We summarize how proteomics, metabolomics, transcriptomics and genomics are all contributing to the identification of new candidate biomarkers that could be developed and used in clinical stroke management.Despite many years of research, no biomarkers for stroke are available to use in clinical practice. Progress in high-throughput technologies has provided new opportunities to understand the pathophysiology of this complex disease, and these studies have generated large amounts of data and information at different molecular levels. The integration of these multi-omics data means that thousands of proteins (proteomics), genes (genomics), RNAs (transcriptomics) and metabolites (metabolomics) can be studied simultaneously, revealing interaction networks between the molecular levels. Integrated analysis of multi-omics data will provide useful insight into stroke pathogenesis, identification of therapeutic targets and biomarker discovery. In this Review, we detail current knowledge on the pathology of stroke and the current status of biomarker research in stroke. We summarize how proteomics, metabolomics, transcriptomics and genomics are all contributing to the identification of new candidate biomarkers that could be developed and used in clinical stroke management.
Despite many years of research, no biomarkers for stroke are available to use in clinical practice. Progress in high-throughput technologies has provided new opportunities to understand the pathophysiology of this complex disease, and these studies have generated large amounts of data and information at different molecular levels. The integration of these multi-omics data means that thousands of proteins (proteomics), genes (genomics), RNAs (transcriptomics) and metabolites (metabolomics) can be studied simultaneously, revealing interaction networks between the molecular levels. Integrated analysis of multi-omics data will provide useful insight into stroke pathogenesis, identification of therapeutic targets and biomarker discovery. In this Review, we detail current knowledge on the pathology of stroke and the current status of biomarker research in stroke. We summarize how proteomics, metabolomics, transcriptomics and genomics are all contributing to the identification of new candidate biomarkers that could be developed and used in clinical stroke management.In this Review, Montaner and colleagues summarize how proteomics, genomics, transcriptomics and metabolomics are contributing to the discovery and development of biomarkers in stroke, and how bringing them together with integromics could provide new biomarkers and therapeutic opportunities.
Author Makris, Konstantinos
Debette, Stephanie
Simats, Alba
Montaner, Joan
Bustamante, Alejandro
Ramiro, Laura
Jickling, Glen C
Sanchez, Jean-Charles
Tiedt, Steffen
Author_xml – sequence: 1
  givenname: Joan
  orcidid: 0000-0003-4845-2279
  surname: Montaner
  fullname: Montaner, Joan
  email: joan.montaner@vhir.org, joan.montaner@vhir.org, joan.montaner@vhir.org
  organization: Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain. joan.montaner@vhir.org
– sequence: 2
  givenname: Laura
  surname: Ramiro
  fullname: Ramiro, Laura
  organization: Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Barcelona, Spain
– sequence: 3
  givenname: Alba
  surname: Simats
  fullname: Simats, Alba
  organization: Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Barcelona, Spain
– sequence: 4
  givenname: Steffen
  orcidid: 0000-0002-8817-8457
  surname: Tiedt
  fullname: Tiedt, Steffen
  organization: Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany
– sequence: 5
  givenname: Konstantinos
  orcidid: 0000-0002-7896-9028
  surname: Makris
  fullname: Makris, Konstantinos
  organization: Clinical Biochemistry Department, KAT General Hospital, Kifissia, Athens, Greece
– sequence: 6
  givenname: Glen C
  surname: Jickling
  fullname: Jickling, Glen C
  organization: Department of Neurology, University of Alberta, Edmonton, AB, Canada
– sequence: 7
  givenname: Stephanie
  surname: Debette
  fullname: Debette, Stephanie
  organization: Department of Neurology, CHU de Bordeaux, Bordeaux, France
– sequence: 8
  givenname: Jean-Charles
  orcidid: 0000-0002-8733-5932
  surname: Sanchez
  fullname: Sanchez, Jean-Charles
  organization: Translational Biomarker Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland
– sequence: 9
  givenname: Alejandro
  surname: Bustamante
  fullname: Bustamante, Alejandro
  organization: Neurovascular Research Laboratory, Vall d'Hebron Institute of Research, Universitat Autònoma de Barcelona, Barcelona, Spain
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32322099$$D View this record in MEDLINE/PubMed
BookMark eNp9kD1PwzAQhi1URD_gB7AgSywsAX_HHlHFl1TEAMyRk1wgbRIX26nUf0-qFgYGpjvpnju990zRqHMdIHROyTUlXN8EQaVmCWEkIVySRB2hCU2lSUSq1Oi3l3qMpiEsCVGKM3qCxpxxxogxE_T63DexbmADDXZtXQRcOY_jJ-CyDoXbgN9iV-G8dq31K_AB267czb1dQx_rAkfrPyDu90L0bgWn6LiyTYCzQ52h9_u7t_ljsnh5eJrfLpJCGh2T3GgrC0WqavhCgrCal4JRIaRloIjMc6kslXlVFTKFIrWGEaYtIbmgvLSWz9DV_u7au68eQszaITM0je3A9SFj3AgmqEj1gF7-QZeu992QLmODrFQZaui_FDcpY1KrHXVxoPq8hTJb-3pws81-pPJvfXV6Ag
CitedBy_id crossref_primary_10_1155_2021_2510847
crossref_primary_10_3928_19382359_20220803_06
crossref_primary_10_1039_D2FO03030F
crossref_primary_10_1021_acsnano_5c01197
crossref_primary_10_1016_j_compbiomed_2023_106639
crossref_primary_10_3390_ijms252313190
crossref_primary_10_1016_j_compbiomed_2022_105825
crossref_primary_10_1136_svn_2021_000885
crossref_primary_10_1161_STROKEAHA_121_032622
crossref_primary_10_1007_s11011_023_01262_y
crossref_primary_10_1002_advs_202305614
crossref_primary_10_1161_JAHA_122_025245
crossref_primary_10_3389_fendo_2025_1574858
crossref_primary_10_1016_j_heliyon_2024_e37168
crossref_primary_10_1093_bib_bbad301
crossref_primary_10_1093_hmg_ddab209
crossref_primary_10_1007_s12035_023_03399_4
crossref_primary_10_1002_adbi_202300613
crossref_primary_10_1007_s13577_023_00912_8
crossref_primary_10_1093_postmj_qgaf032
crossref_primary_10_3390_ijms21249387
crossref_primary_10_3390_gels8120777
crossref_primary_10_1038_s41598_023_37177_y
crossref_primary_10_1111_jcmm_17758
crossref_primary_10_1111_ene_16006
crossref_primary_10_1002_pmic_202200275
crossref_primary_10_1016_j_neuint_2021_105073
crossref_primary_10_1016_j_xcrp_2025_102811
crossref_primary_10_1016_j_nbd_2024_106541
crossref_primary_10_1038_s41598_024_74995_0
crossref_primary_10_1097_WCO_0000000000001011
crossref_primary_10_3389_fnins_2021_700297
crossref_primary_10_1080_10408347_2022_2156770
crossref_primary_10_1038_s41598_024_83783_9
crossref_primary_10_3389_fphar_2022_980650
crossref_primary_10_1016_j_talanta_2024_126710
crossref_primary_10_1161_JAHA_123_032840
crossref_primary_10_1007_s11239_023_02869_9
crossref_primary_10_1080_1354750X_2021_1985171
crossref_primary_10_1002_pmic_202100324
crossref_primary_10_1002_mco2_315
crossref_primary_10_1007_s12035_023_03738_5
crossref_primary_10_3389_fcvm_2022_897106
crossref_primary_10_3390_bios10090107
crossref_primary_10_3389_fcell_2021_746317
crossref_primary_10_1007_s12035_021_02401_1
crossref_primary_10_3389_fneur_2024_1472912
crossref_primary_10_1002_jcla_23756
crossref_primary_10_1002_mco2_261
crossref_primary_10_1007_s00277_024_05655_6
crossref_primary_10_3389_fneur_2022_1101524
crossref_primary_10_1007_s12031_025_02309_8
crossref_primary_10_3389_fphar_2023_1290253
crossref_primary_10_3390_biomedicines8080248
crossref_primary_10_3892_ijmm_2022_5164
crossref_primary_10_1007_s12975_025_01380_y
crossref_primary_10_1016_j_hybadv_2023_100123
crossref_primary_10_1016_j_jstrokecerebrovasdis_2023_107136
crossref_primary_10_1038_s41582_021_00592_8
crossref_primary_10_1186_s43556_024_00237_4
crossref_primary_10_1007_s12031_021_01840_8
crossref_primary_10_1016_j_bioactmat_2025_01_014
crossref_primary_10_1038_s41598_022_16598_1
crossref_primary_10_3390_cells10081854
crossref_primary_10_1016_j_jcis_2023_05_137
crossref_primary_10_1038_s43856_025_00895_7
crossref_primary_10_1093_cei_uxad014
crossref_primary_10_1155_2021_9990020
crossref_primary_10_1186_s13613_025_01550_z
crossref_primary_10_1080_10406638_2023_2261586
crossref_primary_10_1212_WNL_0000000000013165
crossref_primary_10_3389_fphar_2024_1372449
crossref_primary_10_3390_diagnostics10100804
crossref_primary_10_1080_14789450_2020_1807335
crossref_primary_10_1161_CIRCRESAHA_122_320110
crossref_primary_10_3390_life12040602
crossref_primary_10_1161_CIRCRESAHA_122_319950
crossref_primary_10_3390_biology10090843
crossref_primary_10_3389_fneur_2024_1417357
crossref_primary_10_1007_s10238_021_00732_w
crossref_primary_10_3389_fgwh_2020_610582
crossref_primary_10_3389_fnins_2023_1084813
crossref_primary_10_3389_fphar_2022_1052110
crossref_primary_10_3390_life12020230
crossref_primary_10_3389_fimmu_2023_1202436
crossref_primary_10_1016_j_jprot_2022_104603
crossref_primary_10_1016_j_jtha_2023_05_015
crossref_primary_10_3724_SP_J_1123_2023_12011
crossref_primary_10_1016_j_psyneuen_2024_107262
crossref_primary_10_1155_2022_9117205
crossref_primary_10_1016_j_phrs_2024_107313
crossref_primary_10_1016_j_apsb_2023_05_021
crossref_primary_10_1016_j_genrep_2022_101555
crossref_primary_10_1186_s41016_024_00365_4
crossref_primary_10_1002_INMD_20250042
crossref_primary_10_1016_j_jchromb_2021_122808
crossref_primary_10_1097_MD_0000000000039525
crossref_primary_10_1016_j_arr_2022_101730
crossref_primary_10_1016_j_autrev_2025_103898
crossref_primary_10_3389_fimmu_2023_1134956
crossref_primary_10_1016_j_ebiom_2023_104456
crossref_primary_10_1073_pnas_2313851121
crossref_primary_10_1155_2022_5241902
crossref_primary_10_1177_17474930241293408
crossref_primary_10_3389_fnut_2022_994286
crossref_primary_10_1016_j_prmedi_2024_10_002
crossref_primary_10_3389_fnins_2022_1002590
crossref_primary_10_1007_s12031_025_02352_5
crossref_primary_10_1007_s12035_024_04093_9
crossref_primary_10_3233_CH_242435
crossref_primary_10_1007_s00018_024_05426_6
crossref_primary_10_1016_j_mtchem_2023_101499
crossref_primary_10_1007_s10142_025_01573_6
crossref_primary_10_1007_s12035_024_04126_3
crossref_primary_10_1016_j_brainresbull_2024_111031
crossref_primary_10_1177_0271678X21992664
crossref_primary_10_1007_s12264_021_00733_5
crossref_primary_10_1038_s41392_023_01465_w
crossref_primary_10_1007_s10895_023_03441_7
crossref_primary_10_1016_j_heliyon_2024_e28944
crossref_primary_10_1212_WNL_0000000000012833
crossref_primary_10_3390_ijms23126479
crossref_primary_10_1016_j_jep_2021_114302
crossref_primary_10_1016_j_jstrokecerebrovasdis_2023_107467
crossref_primary_10_1186_s40035_023_00370_0
crossref_primary_10_3390_ijms222111678
crossref_primary_10_3390_cells14151149
crossref_primary_10_1093_bib_bbaf355
crossref_primary_10_1080_17520363_2024_2389033
crossref_primary_10_1016_j_talanta_2020_121679
crossref_primary_10_1016_j_jrras_2025_101841
crossref_primary_10_1212_WNL_0000000000012263
crossref_primary_10_1007_s12519_022_00661_y
crossref_primary_10_3389_fneur_2022_846198
crossref_primary_10_1007_s12015_023_10541_1
crossref_primary_10_1016_j_ijbiomac_2025_145531
crossref_primary_10_1093_brain_awae111
crossref_primary_10_1093_bib_bbaf348
crossref_primary_10_1007_s11306_023_01990_3
crossref_primary_10_3389_fphys_2024_1394740
crossref_primary_10_3390_biomedicines11102727
crossref_primary_10_1016_j_expneurol_2025_115396
crossref_primary_10_3389_fimmu_2024_1421942
crossref_primary_10_1038_s41582_023_00908_w
crossref_primary_10_1016_j_heliyon_2023_e14949
crossref_primary_10_1016_j_heliyon_2022_e09616
crossref_primary_10_1016_j_jconrel_2021_12_024
crossref_primary_10_3389_fneur_2023_1201130
crossref_primary_10_1161_STROKEAHA_123_044212
crossref_primary_10_1186_s12864_023_09413_2
crossref_primary_10_1007_s11306_022_01872_0
crossref_primary_10_3390_ijms241813821
crossref_primary_10_2147_IDR_S366580
crossref_primary_10_36425_rehab619331
crossref_primary_10_1186_s12967_025_06531_1
crossref_primary_10_1007_s12035_022_02745_2
crossref_primary_10_1002_advs_202203984
crossref_primary_10_3389_fnagi_2023_1144364
crossref_primary_10_1007_s11011_022_01011_7
crossref_primary_10_1038_s41392_021_00802_1
crossref_primary_10_1016_j_biotechadv_2024_108447
crossref_primary_10_1080_17460441_2024_2324916
crossref_primary_10_2147_JIR_S497525
crossref_primary_10_1186_s13059_024_03401_9
crossref_primary_10_3389_fneur_2021_624930
crossref_primary_10_1186_s12967_025_06698_7
crossref_primary_10_1007_s11427_022_2280_3
crossref_primary_10_1038_s41598_025_88943_z
crossref_primary_10_3390_life11040364
crossref_primary_10_1016_j_neuroscience_2024_04_006
crossref_primary_10_1177_0271678X231170037
crossref_primary_10_1080_01616412_2025_2487867
crossref_primary_10_3390_biomedicines10092147
crossref_primary_10_3390_biom12010039
crossref_primary_10_3389_fmolb_2023_1099654
crossref_primary_10_1016_j_apsb_2022_09_006
crossref_primary_10_1177_0271678X231182244
crossref_primary_10_1186_s12864_023_09647_0
crossref_primary_10_1016_j_neuroscience_2025_02_004
crossref_primary_10_1038_s41565_023_01348_9
crossref_primary_10_1039_D4SC05977H
crossref_primary_10_1002_aisy_202200247
crossref_primary_10_1177_15459683251340926
crossref_primary_10_3389_fphar_2022_814942
crossref_primary_10_1161_JAHA_123_033201
crossref_primary_10_1186_s12967_022_03377_9
crossref_primary_10_3389_fneur_2021_767484
crossref_primary_10_3389_fnins_2024_1443438
crossref_primary_10_1002_adfm_202409522
crossref_primary_10_1016_j_mad_2023_111794
crossref_primary_10_1038_s41440_022_00885_5
crossref_primary_10_2147_JIR_S507083
crossref_primary_10_3389_fphar_2020_600561
crossref_primary_10_1016_j_jep_2022_115766
crossref_primary_10_1002_ana_26552
crossref_primary_10_3389_fphar_2024_1504109
crossref_primary_10_1186_s13073_023_01273_5
crossref_primary_10_1002_ana_26537
crossref_primary_10_1007_s12028_023_01883_2
ContentType Journal Article
Copyright Springer Nature Limited 2020.
Copyright_xml – notice: Springer Nature Limited 2020.
DBID NPM
3V.
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
FYUFA
GHDGH
K9.
M0S
M1P
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
7X8
DOI 10.1038/s41582-020-0350-6
DatabaseName PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central
ProQuest One
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni)
PML(ProQuest Medical Library)
Proquest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle PubMed
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
ProQuest Health & Medical Research Collection
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
Health & Medical Research Collection
ProQuest Central (New)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList PubMed
MEDLINE - Academic
ProQuest One Academic Middle East (New)
ProQuest One Academic Middle East (New)
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1759-4766
EndPage 264
ExternalDocumentID 32322099
Genre Journal Article
Review
GroupedDBID ---
0R~
29M
39C
53G
70F
7X7
88E
8FI
8FJ
AARCD
AAWTL
AAWYQ
AAYZH
ABAWZ
ABJNI
ABLJU
ABUWG
ACGFS
ADBBV
AENEX
AFANA
AFKRA
AFSHS
AGAYW
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ALPWD
ARMCB
AXYYD
BENPR
BKKNO
BPHCQ
BVXVI
CCPQU
DB5
EBS
EE.
EJD
EXGXG
F5P
FQGFK
FSGXE
FYUFA
HMCUK
HZ~
IAO
IGS
IHR
IHW
INH
INR
ITC
M1P
NFIDA
NNMJJ
NPM
ODYON
OVD
PHGZT
PQQKQ
PROAC
PSQYO
RNR
RNT
RNTTT
SHXYY
SIXXV
SNYQT
SOJ
TAOOD
TBHMF
TDRGL
TEORI
TSG
UKHRP
3V.
7XB
8FK
ABFSG
ACSTC
AEZWR
AFHIU
AGSTI
AHWEU
AIXLP
ATHPR
K9.
PHGZM
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
7X8
PUEGO
ID FETCH-LOGICAL-c598t-b98a5c60ff1585e4a83d421445a2e605bb56a15bffc57ec7a92028a00b413daa3
IEDL.DBID 7X7
ISICitedReferencesCount 235
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000528101100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1759-4758
1759-4766
IngestDate Thu Oct 02 12:14:11 EDT 2025
Sat Nov 29 14:41:17 EST 2025
Sat Nov 29 15:06:49 EST 2025
Thu Apr 03 06:59:47 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 5
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c598t-b98a5c60ff1585e4a83d421445a2e605bb56a15bffc57ec7a92028a00b413daa3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0003-4845-2279
0000-0002-7896-9028
0000-0002-8817-8457
0000-0002-8733-5932
PMID 32322099
PQID 2397225861
PQPubID 2041930
PageCount 18
ParticipantIDs proquest_miscellaneous_2394241478
proquest_journals_2476769191
proquest_journals_2397225861
pubmed_primary_32322099
PublicationCentury 2000
PublicationDate 2020-05-01
PublicationDateYYYYMMDD 2020-05-01
PublicationDate_xml – month: 05
  year: 2020
  text: 2020-05-01
  day: 01
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Nature reviews. Neurology
PublicationTitleAlternate Nat Rev Neurol
PublicationYear 2020
Publisher Nature Publishing Group
Publisher_xml – name: Nature Publishing Group
SSID ssj0066321
Score 2.6566882
SecondaryResourceType review_article
Snippet Despite many years of research, no biomarkers for stroke are available to use in clinical practice. Progress in high-throughput technologies has provided new...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 247
SubjectTerms Biomarkers
Genomics
Proteomics
Title Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke
URI https://www.ncbi.nlm.nih.gov/pubmed/32322099
https://www.proquest.com/docview/2397225861
https://www.proquest.com/docview/2476769191
https://www.proquest.com/docview/2394241478
Volume 16
WOSCitedRecordID wos000528101100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEB50FfHi-7G6SgSvYWubNOlJVBQvlsUH7G1J0hREaXW7Cv57Z9ru6kG9eCmU0AfTaeabzPdlAI4TGWTWBo4HniQ51ipuRCY5xr7ICZ1oZ7K62YRKUz0cJoN2wa1qaZXTObGeqLPS0Rp5P8TAib6n45PTl1dOXaOoutq20JiHBWqbTX6uhrOEC4Npo7tSMuECgfG0qhnpfoWBC7ElJU9UW-Px7wizjjRXq_99xzVYaTEmO2ucYh3mfLEBSzdtFX0T7mrV7TPRhRiJkiuGyJUhEmSk0SVO5wcrc0bKfCLvjCtmiox9U2qxhj_eXFdNxuWT34KHq8v7i2veNlfgTiZ6wm2ijXRxkOdoCOmF0VEmaP80aUKPOY61MjYn0ua5k8o7ZZIQoYgJAothLzMm2oZOURZ-F5jLMW90BrGEob0OjZE2CzDqWZ0LlTjbhd7UXKP2D6lGX7b6eVgoIt9iNtmFo9kwuj7VM0zhy7f6FgIBiFC6CzvNFxu9NHt0jCJEiqQK3vv72fuwHNY-QAzGHnQm4zd_AIvuffJYjQ9rb6qP-hAWzi_TwS2epYObT90O1gU
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1NT9tAEB2lKSq9tFA-mpaPrdQeVzj2bnZ9qKoKGgUBERKplJvZXa8l1MqGOGmVP8VvZMaOgQP0lkPPK69l73jmjee9GYDPsQxSawPHA0-SHGsVNyKVHGNf5ISOtTNpNWxCDYd6PI7PW3DbaGGIVtn4xMpRp4Wjf-QHIQZOtD3d6367vuE0NYqqq80IjdosTvz8L6Zs5dfjIzzfL2HY_zE6HPDFVAHuZKyn3MbaSNcLsqyLUNkLo6NUUOMwaUKP4N5a2TNdabPMSeWdMnGIMdgEgUV_nxoT4b4v4CX6cUXJnhrfJ3gYvGudl5IxFwjEmypqpA9KDJSIZSlZo1oe7z2PaKvI1n_7v72TNXizwNDse23069Dy-Tt4dbZgCWzARaUq_k10KEai65IhMmeIdBlpkImzOmdFxqjzAJGTJiUzecoeKdFYzY-vryunk-KX34SfS3mkLWjnRe7fA3MZ5sXOIFYy1MvRGGnTAKO61ZlQsbMd2GmOJ1l4gDJ5OJunl4UicjFmyx34dL-MnzbVa0zui1m1hUCAJZTuwHZtIcl13YMkiRAJk-r5w7_vvQ-rg9HZaXJ6PDz5CK_Dyv6IrbkD7elk5ndhxf2ZXpWTvcqSGVwu20zuAIGkL4U
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VFEVcKAUKoYVuJTiu4ti72fUBVX0koipEEQ8pN7O7XksIZIc4AfWv9dd1xo_SQ-kth55XtmXv7HzfeL6ZAXgbyyC1NnA88FSSY63iRqSSI_ZFTuhYO5NWwybUZKJns3i6AZdtLQzJKlufWDnqtHD0j7wfInCi7enhoJ81sojp6fhw_pvTBCnKtLbjNGoTOfcXfzF8K9-fneJevwvD8ejryQfeTBjgTsZ6yW2sjXTDIMsGSJu9MDpKBTURkyb0SPStlUMzkDbLnFTeKROHiMcmCCz6_tSYCO_7ADYVkgzRgc3j0WT6ucUBhPK66kvJmAuk5W1ONdL9EmETmS2FbpTZ48P_89sK58Zb9_kLPYHHDbtmR_Vx2IYNnz-F7qdGP_AMvlT1xr9IKMWoHLtkyNkZcmBG1cmkZr1gRcaoJwHJlhYlM3nKbtSosVo5X19XLhfFT_8cvq3llXagkxe5fwnMZRgxO4MsylCXR2OkTQPEe6szoWJne7DXblXS-IYy-bdPty8LRbJjjKN7cHC9jIeeMjkm98WquoVA6iWU7sGL2lqSed2dJImQI1M99Ku7n70PXbSO5OPZ5HwXHoWVKZKMcw86y8XKv4aH7s_yR7l405g1g-_rtpMrOLk5pQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Multilevel+omics+for+the+discovery+of+biomarkers+and+therapeutic+targets+for+stroke&rft.jtitle=Nature+reviews.+Neurology&rft.au=Montaner%2C+Joan&rft.au=Ramiro+Laura&rft.au=Simats+Alba&rft.au=Tiedt+Steffen&rft.date=2020-05-01&rft.pub=Nature+Publishing+Group&rft.issn=1759-4758&rft.eissn=1759-4766&rft.volume=16&rft.issue=5&rft.spage=247&rft.epage=264&rft_id=info:doi/10.1038%2Fs41582-020-0350-6&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1759-4758&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1759-4758&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1759-4758&client=summon