The association between rheumatoid arthritis and periodontitis

The relationship between rheumatoid arthritis and poor oral health has been recognised for many decades. The association between periodontal infection and the risk of developing RA has been the subject of epidemiological, clinical and basic science research in recent times. Converging and reproducib...

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Veröffentlicht in:Best practice & research. Clinical rheumatology Jg. 29; H. 2; S. 189 - 201
Hauptverfasser: Leech, Michelle T., Bartold, P.M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ltd 01.04.2015
Schlagworte:
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - microbiology
Bacteroidaceae Infections - microbiology
Citrullination
Humans
Hydrolases - metabolism
Peptidylarginine deiminase (PAD)
Periodontitis (PD)
Periodontitis - microbiology
Porphyromonas gingivalis
Porphyromonas gingivalis - enzymology
Porphyromonas gingivalis - pathogenicity
Protein-Arginine Deiminases
Rheumatoid arthritis (RA)
Rheumatology
Rheumatoid arthritis (RA)
Porphyromonas gingivalis
Citrullination
Periodontitis (PD)
Peptidylarginine deiminase (PAD)
ISSN:1521-6942, 1532-1770
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Zusammenfassung:The relationship between rheumatoid arthritis and poor oral health has been recognised for many decades. The association between periodontal infection and the risk of developing RA has been the subject of epidemiological, clinical and basic science research in recent times. Converging and reproducible evidence now makes a clear case for the role of specific periodontal infective pathogens in initiating, amplifying and perpetuating rheumatoid arthritis. The unique enzymatic properties of the periodontal pathogen Porphyromonas gingivalis and its contribution to the burden of citrullinated peptides is now well established. The impact of localized infection such as periodontitis in shaping specific anti-citrullinated peptide immune responses highlights a key area for treatment, prevention and risk assessment in rheumatoid arthritis.
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ObjectType-Feature-3
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ISSN:1521-6942
1532-1770
DOI:10.1016/j.berh.2015.03.001